日用化学品科学2025，Vol.48Issue(12)：16-23,8.DOI:10.3969/j.issn.1006-7264.2025.12.003
祛痘功效成分复合载体经皮渗透及抑菌抗炎功效研究
Study on transdermal penetration and antibacterial-anti-inflammatory efficacy of acne-fighting composite carriers
LIU Ting 1CHEN Dan 2YI Ou 1LUO Dan 2LIU Rui 2LIU Wei2
作者信息
- 1. Wuhan Beauty Evolution Information Technology Co.,Ltd.,Wuhan,Hubei 430074,China
- 2. Wuhan Bestcarrier Biotechnology Co.,Ltd.,Wuhan,Hubei 430075,China||National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan,Hubei 430075,China
- 折叠
摘要
Abstract
The safety,transdermal permeability,and antibacterial and anti-inflammatory efficacy of acne-fighting composite carriers,including nanoemulsions loaded with mandelic acid,magnolol,and bisabolol,and liposomes loaded with acetyl dipeptide-1 cetearyl ester and matrine was evaluated.HET-CAM(hen's egg chorioallantoic membrane)tests confirmed the carriers'good safety profile,showing no skin irritation.Transdermal permeation studies demonstrated that the composite carriers enhance penetration of active ingredients into the skin while maintaining high local concentrations.Antibacterial assays,including paper diffusion and minimum inhibitory concentration(MIC)tests,indicated that the composite carriers effectively inhibit Staphylococcus aureus and Propionibacterium acnes.Cellular experiments revealed that the carriers significantly suppressed secretion of inflammatory cytokines IL-1β,IL-6,IL-8,and PGE2,exhibiting superior anti-inflammatory efficacy compared with the free active components at equivalent concentrations.关键词
祛痘复合载体/安全性/经皮渗透/抑菌功效/抗炎功效Key words
acne-fighting composite carrier/safety/transdermal penetration/antibacterial efficacy/anti-inflammatory efficacy分类
化学化工引用本文复制引用
LIU Ting,CHEN Dan,YI Ou,LUO Dan,LIU Rui,LIU Wei..祛痘功效成分复合载体经皮渗透及抑菌抗炎功效研究[J].日用化学品科学,2025,48(12):16-23,8.
