日用化学品科学2025，Vol.48Issue(12)：43-52,10.DOI:10.3969/j.issn.1006-7264.2025.12.007
海藻中不同形态植物甾醇的提取鉴定及其改善脂溢性脱发研究
Extraction and identification of phytosterols forms from seaweed and their effects on seborrheic hair loss
摘要
Abstract
Phytosterols of different forms were extracted from four types of seaweed and evaluated for their anti-hair loss and oil-control effects.Under optimal conditions,fucosterol from Undaria pinnatifida contained(3 217.97±16.04)μg/g,with purified fucosterol reaching 96.87%±2.14%purity.Extracts and purified products obtained via saponification and acid hydrolysis followed by alkali saponification effectively inhibited lipid synthesis in sebaceous gland cells,suppressing sebum secretion.Fucosterol and β-sitosterol inhibited Dickkopf-1(DKK-1)expression and reduced interleukin-6(IL-6)secretion in human dermal papilla cells(DPCs),with downregulation rates of 36.94%and 39.49%,respectively,and inhibition rates of 19.14%and 23.56%.This study elucidates the content and distribution characteristics of various phytosterols in seaweed,highlighting their potential application in managing seborrheic hair loss.关键词
植物甾醇/甾醇纯化/脂质抑制/脱发Key words
phytosterols/sterol purification/lipid inhibition/hair loss分类
化学化工引用本文复制引用
FENG Simin,GUO Baihui,FANG Yuanyuan,CHANG Xiaowei,SHAO Ping..海藻中不同形态植物甾醇的提取鉴定及其改善脂溢性脱发研究[J].日用化学品科学,2025,48(12):43-52,10.基金项目
国家自然科学面上基金(32472367) （32472367）
浙江省自然科学基金重点项目(HZSZ25C200001) （HZSZ25C200001）
