兽类学报2025，Vol.45Issue(6)：771-783,13.DOI:10.16829/j.slxb.151059
单细胞转录组测序在哺乳动物内耳研究中的应用前景
The prospective applications of single-cell transcriptome sequencing in mammalian inner ear research
摘要
Abstract
The inner ear,as the core organ responsible for hearing and balance,possesses an intricate structure with diverse cell types.Single-cell RNA sequencing technology(scRNA-Seq)enables the capture and analysis of gene expression pro-files at the individual cell level,providing a powerful tool for in-depth exploration of the functions and molecular mecha-nisms of the inner ear.We review the significant applications of scRNA-Seq in inner ear research from 2015 to 2024,highlighting important advances in revealing cellular heterogeneity,tracing inner ear development processes,investigat-ing hearing loss mechanisms,and cell regeneration researches.We also discuss the potential application of scRNA-Seq technology in addressing key scientific questions in wildlife research and explore the prospects of single-cell multi-omics techniques in uncovering the adaptive evolution and molecular mechanisms of the mammalian inner ear.关键词
细胞异质性/听力损伤/毛细胞再生/发育生物学/适应性进化Key words
Cellular heterogeneity/Hearing loss/Hair cell regeneration/Developmental biology/Adaptive evolution分类
生物科学引用本文复制引用
ZHANG Mengdie,ZHU Bicheng,HE Guanglin,ZHANG Yuzhong,JIAN Jinchan,SHEN Anqi,LIU Yunzhu,HE Kai..单细胞转录组测序在哺乳动物内耳研究中的应用前景[J].兽类学报,2025,45(6):771-783,13.基金项目
国家自然科学基金面上项目(32370536) （32370536）
广东省自然科学基金杰出青年(2022B1515020033) （2022B1515020033）
国家自然科学基金面上项目(32170452) （32170452）
