生物信息学2025，Vol.23Issue(4)：249-260,12.DOI:10.12113/202408007
内部核糖体进入位点(IRES)计算识别方法的研究进展
Review of computational methods for predicting internal ribosome entry site(IRES)
摘要
Abstract
Internal ribosome entry site(IRES)is a cis-regulatory element that can initiate translation in cap-independent manner.It was first discovered in viral RNA sequences,and then cellular mRNAs were found to contain IRESs.Recently,IRES elements have also been reported in circRNAs and mediate their translation.Cap-independent translation mediated by IRES plays important roles in many cellular processes and is involved in many human diseases,receiving more and more attentions.Since identifying IRES elements by experimental method is time-consuming and laborious,faster and more convenient computational methods have been developed based on experimentally validated data.In this paper,we briefly introduce IRES elements,summarize existing IRES predicting methods,and compare their prediction performance on an independent testing dataset.关键词
内部核糖体进入位点/非帽依赖/翻译调控/机器学习/深度学习Key words
Internal ribosome entry site/Cap-independent translation/Translation regulation/Machine learning/Deep learning分类
医药卫生引用本文复制引用
CHEN Zhewei,ZHANG Meng,SONG Xiaofeng,ZHAO Jian..内部核糖体进入位点(IRES)计算识别方法的研究进展[J].生物信息学,2025,23(4):249-260,12.基金项目
国家自然科学基金面上项目(No.62273175) （No.62273175）
江苏省重点研发计划项目(No.BE2022843) （No.BE2022843）
中央高校基本科研业务费资助(No.1003-XAA23018). （No.1003-XAA23018）
