云南民族大学学报（自然科学版）2025，Vol.34Issue(6)：638-647,10.DOI:10.3969/j.issn.1672-8513.2025.06.002
三七治疗肺纤维化的分子机制研究
Exploration of the molecular mechanism of Panax notoginseng in treating pulmonary fibrosis
摘要
Abstract
The mechanism of action of Panax notoginseng in the treatment of pulmonary fibrosis was explored by utilizing Gene Expression Omnibus(GEO)chip mining and network pharmacology.The active components of P.notoginseng and their corresponding targets were collected.Databases were integrated to obtain therapeutic targets for pulmonary fibrosis,and intersecting targets for P.notoginseng in the treatment of pulmonary fibrosis were identified.A"drug-active component-target"network diagram and a PPI network were constructed,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were conducted.Finally,molecular docking verification was performed.The results suggest that P.notoginseng may play a role in the treatment of pulmonary fibrosis by regulating pathways related to antioxidant activity,inflammatory response,immune regulation,and autophagy in lung tissues through active ingredients such as quercetin,β-sitosterol,and mannitol.关键词
三七/网络药理学/肺纤维化/分子对接/信号通路/分子机制Key words
Panax notoginseng/network pharmacology/pulmonary fibrosis/molecular docking/signaling path/molecular mechanism分类
医药卫生引用本文复制引用
LIU Li,HUANG Jian-hua,ZHOU Yi-fei,LAI Chun-bing,CHEN Bo,LIU Rui..三七治疗肺纤维化的分子机制研究[J].云南民族大学学报（自然科学版）,2025,34(6):638-647,10.基金项目
国家自然科学基金(81860829) （81860829）
广西科学基金(2020GXNSFAA297158,2018GXNSFAA050108). （2020GXNSFAA297158,2018GXNSFAA050108）
