云南民族大学学报（自然科学版）2025，Vol.34Issue(6)：648-655,8.DOI:10.3969/j.issn.1672-8513.2025.06.003
新型蒙药"苏格木勒-3颗粒"的制备及处方工艺优化
Preparation and process optimization of the novel Mongolian medicine"Sugemule-3 Granules"
摘要
Abstract
The novel Mongolian medicine"Sugemule-3 Granules"was prepared,and its extraction and formulation process was optimized.The volatile oil extraction process of Sugemule-3 was optimized by single-factor analysis;the extraction process of the non-volatile components was optimized by orthogonal test;the preparation process of Sugemule-3 Granules was optimized by single-factor experiments and orthogonal experiments,ultimately determining the volatile oil extraction conditions.The optimal volatile oil extraction was achieved with coarse medicinal granules soaked for 1 h,a reflux rate of 7.5 mL/min,a solid-liquid ratio of 1∶8 g/mL,and an extraction time of 2 h.The extraction process for non-volatile components used ethanol with a volume fraction of 65%,solid-liquid ratio of 1∶15 g/mL,extraction time of 50 min,and 3 extraction cycles.The optimal formulation and preparation process for Sugemule-3 Granules were screened,with an average yield of 95.50%.The extraction process is simple and efficient,and the granule preparation process is feasible,providing a foundation for the development of Sugemule-3 and a scientific experimental basis for its quality control.关键词
苏格木勒-3颗粒/制备工艺/正交试验设计/质量评价Key words
Sugemule-3 Granules/preparation process/orthogonal test design/quality evaluation分类
医药卫生引用本文复制引用
ZHANG Hong,LIU Hong,ZHANG Chen,ZHANG Hui-wen,WANG Huan-yun..新型蒙药"苏格木勒-3颗粒"的制备及处方工艺优化[J].云南民族大学学报（自然科学版）,2025,34(6):648-655,8.基金项目
内蒙古自治区自然科学基金(2022MS08023) （2022MS08023）
内蒙古自治区蒙医药协同创新中心科学研究项目(MYYX-TYB202108) （MYYX-TYB202108）
内蒙古自治区教育科学"十三五"规划课题(NGJGH2020277) （NGJGH2020277）
内蒙古医科大学校级创新训练项目(202210132062). （202210132062）
