云南民族大学学报（自然科学版）2025，Vol.34Issue(6)：666-675,10.DOI:10.3969/j.issn.1672-8513.2025.06.005
基于代谢组学的茯苓皮、茯苓、茯神药效机制研究进展
Research progress on the pharmacological mechanisms of three medicinal parts from Poria cocos(Schw.)Wolf based on metabolomics
摘要
Abstract
As recorded in the Chinese Pharmacopoeia(2020 edition),Poria cocos(Schw.)Wolf refers to the dried sclerotium of this fungus.It has been used as a traditional Chinese medicine for more than two thousand years and is known by the saying"ten prescriptions,nine with poria".According to differences in their medicinal parts and efficacy,the sclerotium is divided into three parts:Poriae cutis(Fulingpi),Poria(Fuling),and Poria cum Radix Pini(Fushen).Metabolomics,which can detect dynamic changes of endogenous small-molecule metabolites in biological systems and perform qualitative and quantitative analysis,is often used to study the mechanisms of multi-component and multi-target therapies in traditional Chinese medicine.This review integrates relevant domestic and international literature to summarize research advances in the pharmacodynamic mechanisms of Poriae cutis,Poria,and Poria cum Radix Pini based on metabolomics.It aims to provide a more comprehensive theoretical basis for disease treatment using these related medicinal parts of Poria cocos sclerotium,promote their better development and utilization,and offer new insights into revealing the scientific connotation of the therapeutic effects of traditional Chinese medicine.关键词
茯苓皮/茯苓/茯神/代谢组学/研究进展Key words
Poriae cutis/Poria/Poria cum Radix Pini/metabolomics/research progress分类
医药卫生引用本文复制引用
ZHONG Yue-tong,LIU Shu-qiong,HUANG Xing-lin,JIANG Zhong-min,ZHANG Guo-qiong,YANG Ze-rong,LI Lin-zhe,HE Sen,ZHANG Mei..基于代谢组学的茯苓皮、茯苓、茯神药效机制研究进展[J].云南民族大学学报（自然科学版）,2025,34(6):666-675,10.基金项目
国家自然科学基金(82160748) （82160748）
云南省兴滇英才青年人才支持项目(XDYC-QNRC-2022-0475) （XDYC-QNRC-2022-0475）
云南省科技厅应用基础研究联合专项(202401AZ070001-010). （202401AZ070001-010）
