湖北医药学院学报2025，Vol.44Issue(6)：681-686,6.DOI:10.13819/j.issn.2096-708X.2025.06.005
PDCD4通过AKT-BDNF途径参与术后谵妄
PDCD4 Contributes to Postoperative Delirium Through the AKT-BDNF Pathway
摘要
Abstract
Objective To explore the role of PDCD4 in postoperative delirium through the AKT-BDNF pathway.Methods The delirium-like behaviors were observed by constructing an anesthesia/surgery mouse model.Western blot was performed to assess the protein levels of PDCD4,AKT,p-AKT,p-CREB,and BDNF in the hippocampus of mice.Behavioral and protein changes were further verified using PDCD4 knockout mice and administering an overexpression virus.Results Be-havioral tests indicated that mice undergoing anesthesia/surgery exhibited delirium-like behaviors,with elevated PDCD4 in the hippocampus and inhibited AKT-BDNF pathway.PDCD4 knockout mice had improved delirium-like behaviors,along with activation of the AKT-BDNF pathway.Moreover,delirium-like behaviors were also observed in wild-type(WT)mice after the injection of the PDCD4 overexpression virus into the hippocampus.Conclusion PDCD4 is involved in postopera-tive delirium through the AKT-BDNF pathway.关键词
术后谵妄/细胞程序性死亡基因4/蛋白激酶B/脑源性神经营养因子Key words
Postoperative delirium/PDCD4/AKT/Brain-derived neurotrophic factor引用本文复制引用
JIA Jie,QU Xin-yang,XI Zheng-hao,WU Fu-yun..PDCD4通过AKT-BDNF途径参与术后谵妄[J].湖北医药学院学报,2025,44(6):681-686,6.基金项目
湖北省科技厅项目(2023AFB882) （2023AFB882）
湖北医药学院博士科研启动金(2024QDJZR034) （2024QDJZR034）
