中国临床药理学杂志2025，Vol.41Issue(19)：2706-2710,5.DOI:10.13699/j.cnki.1001-6821.2025.19.002
噻托溴铵联合布地奈德福莫特罗在老年慢阻肺中的临床研究
Clinical trial of combined application of tiotropium bromide and budesonide formoterol in elderly patients with chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the effect of tiotropium bromide combined with budesonide formoterol on elderly patients with chronic obstructive pulmonary disease(COPD).Methods Using the random number table method,the patients with COPD admitted to our hospital from January 2020 to November 2023 were divided into two groups:the control group received conventional treatment and used budesonide formoterol;the other group received the same treatment as the control group plus tiotropium bromide,serving as the experimental group.The blood gas analysis indicators,inflammation-related indicators,quality of life,clinical efficacy,and safety were compared between the two groups.Results After treatment,arterial partial pressure of oxygen(PaO2),generic quality of life inventory 74(GQOLI-74)scores in the experimental group increased,while partial pressure of carbon dioxide(PaCO2),interleukin-6(IL-6),C-reactive protein(CRP)and procalcitonin(PCT)decreased,which were more significant than those in the control group(P＜0.05).The experimental group's overall efficacy rate was 98.33％,significantly better than the control group's 80.00％(P＜0.05).There was no statistically significant difference in adverse reactions between the experimental group(15.00％)and the control group(10.00％)(P＞0.05).Conclusion Tiotropium bromide in combination with budesonide formoterol can effectively regulate blood gas analysis and the level of inflammation,improve quality of life and enhance clinical efficacy.关键词
布地奈德福莫特罗剂型/噻托溴铵剂型/慢阻肺/血气分析/血清降钙素原Key words
budesonide formoterol/tiotropium bromide/chronic obstructive pulmonary disease/blood gas analysis/serum procalcitonin分类
医药卫生引用本文复制引用
LI Yu-xia,WANG Fang,WU Ya..噻托溴铵联合布地奈德福莫特罗在老年慢阻肺中的临床研究[J].中国临床药理学杂志,2025,41(19):2706-2710,5.基金项目
芜湖市第一人民医院关于下达2022年院级科研项目库入库及立项基金资助项目(2022WYY020I) （2022WYY020I）
