中国临床药理学杂志2025，Vol.41Issue(19)：2754-2759,6.DOI:10.13699/j.cnki.1001-6821.2025.19.010
环泊酚联合阿芬太尼抑制老年胃镜进镜反应半数有效量的研究
The research of the median effective dose of ciprofol combined with alfentanil to in-hibit responses to gastroscopy in elderly patients
摘要
Abstract
Objective To investigate the median effective dose(ED50)of ciprofol combined with alfentanil inhibiting responses to gastroscopy in geriatric patients.Methods A total of 115 elderly patients scheduled for elective painless gastroscopy were enrolled in this study.Patients scheduled for gastroscopy were divided into four groups according to age and gender:Group A consisted of males aged 65-74 years,Group B consisted of females aged 65-74 years,Group C consisted of males aged 75-85 years,and Group D consisted of females aged 75-85 years.Based on the modified Dixon sequential test method,intravenous alfentanil 4 ug·kg-1 was administered followed by ciprofol,with an initial dose of 0.3 mg·kg-1 and the injection time was longer than 30 s,and the dose gradient was set at 0.03 mg·kg-1.The ED50,95％effective dose(ED95),and their 95％confidence intervals(CIs)for gastroscopic response in the four patient groups were calculated using probit regression analysis.Additionally,vital signs were documented for all groups.Results The calculated ED50 and its 95％CI for the dosage of ciprofol in the four groups of elderly patients were 0.19(0.17-0.21)mg·kg-1 in group A,0.20(0.18-0.22)mg·kg-1 in group B,0.15(0.12-0.18)mg·kg-1 in group C,0.17(0.15-0.19)mg·kg-1 in group D.The ED95 and its 95％CI were 0.23(0.09-0.32)mg·kg-1 for Group A,0.25(0.23-0.30)mg·kg-1 for Group B,0.20(0.18-0.38)mg·kg-1 for Group C,and 0.21(0.19-0.31)mg·kg-1 for Group D.There was no statistically significant difference in the ED50 of ciprofol between genders within the same age group(P＞0.05).However,the ED50 of ciprofol in patients aged 75-85 was significantly lower than that in patients aged 65-74 of the same gender(P＜0.05).The Hosmer-Lemeshow test indicated that the Probit models for all four groups fitted well(P＞0.05).Conclusion The ED50 and its 95％CI for the inhibition of the entry response during painless gastroscopy in elderly patients by ciprofol combined with 4.00 ug·kg-1 alfentanil were 0.19(0.17-0.21)mg·kg-1 in group A,0.20(0.18-0.22)mg·kg-1 in group B,0.15(0.12-0.18)mg·kg-1 in group C,0.17(0.15-0.19)mg·kg-1 in group D.Age-stratified dosage adjustment of ciprofol is necessary to minimize adverse reactions.关键词
环泊酚/老年患者/内镜检查/半数有效量Key words
ciprofol/geriatric patients/endoscopic procedures/median effective dose(ED50)分类
医药卫生引用本文复制引用
XIONG Yi-qun,PAN Hao-wei,WAN Hai-fang..环泊酚联合阿芬太尼抑制老年胃镜进镜反应半数有效量的研究[J].中国临床药理学杂志,2025,41(19):2754-2759,6.基金项目
浙江省杭州市生物医药和健康产业发展扶持科技专项(No.2022WJC111) （No.2022WJC111）
