中国临床药理学杂志2025，Vol.41Issue(20)：2863-2868,6.DOI:10.13699/j.cnki.1001-6821.2025.20.003
西尼莫德在复发型多发性硬化患者中的疗效与安全性的病例系列研究
A case series study of the efficacy and safety of siponimod in patients with relapsing multiple sclerosis
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of siponimod tablets in patients with relapsing multiple sclerosis(RMS)through a case series study.Methods Patients meeting inclusion criteria from the department of neurology were enrolled.Demographic data,disease characteristics,medication history and laboratory/imaging results were collected.Efficacy was assessed at baseline,3 months and 6 months after siponimod tablets medication using 3 dimensions:the expanded disability status scale(EDSS),patient-reported outcomes(PRO),and disease activity.Safety was concurrently evaluated.Results A total of 7 patients were included.After 6 months of siponimod tablets treatment,median EDSS score decreased from 7.00 to 6.50;EQ-5D-5L utility index median increased from-0.06 to 0.20;EQ-5D-5L VAS median score rose from 52.86 to 63.57;MSIS-29v2 physical mean score decreased from 64.52 to 54.52;MSIS-29v2 psychological mean score declined from 51.85 to 44.44;MSWS-12 mean score reduced from 80.06 to 75.00.Magnetic resonance imaging(MRI)results indicated decreased disease activity,which was also observed in patients converting from teriflunomide to siponimod treatment.Adverse drug reactions including lymphopenia(2 cases),elevated transaminases(1 case)and hypertension(1 case)were all considered treatment-related.Conclusion Siponimod tablets may be a therapeutic option for RMS patients,though larger studies are needed to confirm efficacy.Pre-treatment assessment of complete blood count and liver function is essential.If clinically significant adverse drug reactions occur during the treatment period,adjustments to the dosage or combined medication should be considered.关键词
西尼莫德片/多发性硬化/疗效/安全性/病例系列Key words
siponimod tablet/multiple sclerosis/efficacy/safety/case sery分类
医药卫生引用本文复制引用
CHEN Chao-yang,WANG Jian-chun,XU Ming-zhu,WEI Ran,LIU Ran,GAO Feng,YUAN Yun,ZHOU Ying..西尼莫德在复发型多发性硬化患者中的疗效与安全性的病例系列研究[J].中国临床药理学杂志,2025,41(20):2863-2868,6.基金项目
北京大学第一医院青年临床研究专项基金资助项目(2024YC25) （2024YC25）
北京大学第一医院科研种子基金资助项目(2024SF04) （2024SF04）
