冠状动脉微血管疾病实验动物模型的研究进展
Research progress in experimental animal models of coronary microvascular disease
摘要
Abstract
Coronary microvascular disease(CMVD)is a clinical syndrome characterized by myocardial ischemia caused by structural or functional abnormalities of the coronary precapillary arterioles,small arteries,and capillaries,resultsing from atherosclerotic or non-atherosclerotic pathogenic factors.Given the complex pathogenesis of CMVD,its increasing incidence,and the challenges in clinical diagnosis,it is crucial to develop animal models that can comprehensively reflect the disease's characteristics and use these models to develop targeted therapeutic agents.Current approaches to constructing CMVD animal models primarily involve increasing hemodynamic load and disrupting metabolism to simulate secondary microvascular changes caused by diseases such as hypertension and diabetes,or directly inducing microvascular obstruction through surgical ligation of the coronary arteries or injection of thrombogenic agents.This article systematically reviews the characteristics of commonly used experimental animals in CMVD models,summarizes the method of model construction,the indications,and their advantages and disadvantages,to provide a reference for basic research in CMVD.关键词
冠状动脉微血管疾病/动物模型/造模方法/研究进展Key words
coronary microvascular disease/animal model/modeling method/research progress分类
生物科学引用本文复制引用
HUANG Ke,ZUO Keke,GU Ning..冠状动脉微血管疾病实验动物模型的研究进展[J].中国实验动物学报,2025,33(11):1648-1662,15.基金项目
国家自然科学基金面上项目(81774229),第四批江苏省名老中医药专家传承工作室建设项目(苏中医科教[2021]7号),江苏省中医药科技发展计划面上项目(MS2023049),南京中医药大学自然科学基金项目(XZR2023063),南京市中医药青年人才培养计划项目(ZYQ20043),江苏省研究生科研与实践创新计划项目(SJCX_1071). Funded by National Natural Science Foundation of China General Project(81774229),Jiangsu Province Famous and Senior Traditional Chinese Medicine Experts Inheritance Studio Construction Project of the Fourth Batch(Su Zhongyi Kejiao[2021]No.7),Jiangsu Province Traditional Chinese Medicine Science and Technology Development Plan General Project(MS2023049),Nanjing University of Chinese Medicine Natural Science Foundation Project(XZR2023063),Nanjing Youth Talent Training Program in Traditional Chinese Medicine(ZYQ20043),Postgraduate Research and Practice Innovation Program of Jiangsu Province(SJCX_1071). （81774229）
