中国实用妇科与产科杂志2025，Vol.41Issue(11)：1079-1084,6.DOI:10.19538/j.fk2025110106
粒细胞集落刺激因子在生殖医学领域应用进展
Progress in the application of granulocyte colony-stimulating factor in the field of reproductive medicine
摘要
Abstract
Granulocyte colony-stimulating factor(G-CSF)is an important hematopoietic cytokine that has recently gained attention for its potential role in reproductive medicine.Basic researches show that G-CSF contributes to oocyte maturation and early embryo development,while affecting reproductive outcomes by improving endometrial receptivity,and modulating the maternal-fetal immune microenvironment.Clinically,G-CSF has been evaluated as an adjuvant therapy for thin endometrium,recurrent implantation failure(RIF),and unexplained recurrent spontaneous abortion(URSA).Current studies suggest that G-CSF may increase endometrial thickness in some patients with thin endometrium,improve implantation rate in RIF population,and reduce miscarriage risk in URSA patients through immunoregulatory effects.However,related studies have differences in patient selection,administration route,dosage,and timing,leading to inconsistent results.Moreover,data on long-term maternal and neonatal safety remain limited,and its clinical application is still debated.In the future,large,multicenter randomized controlled trials are needed to systematically evaluate the efficacy and safety and explore optimal treatment protocols in order to provide evidence for individualized and evidence-based treatment.关键词
粒细胞集落刺激因子/生殖医学/薄型子宫内膜/反复种植失败/不明原因复发性流产Key words
granulocyte colony-stimulating factor/reproduc-tive medicine/thin endometrium/recurrent implantation failure/unexplained recurrent spontaneous abortion分类
医药卫生引用本文复制引用
LI Xin,KANG Xiao-min..粒细胞集落刺激因子在生殖医学领域应用进展[J].中国实用妇科与产科杂志,2025,41(11):1079-1084,6.基金项目
国家自然科学基金(82260311,82460308) National Natural Science Foundation of China(82260311,82460308) （82260311,82460308）
