中国实用妇科与产科杂志2025，Vol.41Issue(11)：1084-1088,5.DOI:10.19538/j.fk2025110107
复发性流产合并未分化结缔组织病的诊治
Diagnosis and treatment of recurrent spontaneous aboration combined with undifferentiated connective tissue disease
摘要
Abstract
Undifferentiated connective tissue disease(UCTD)is a systemic autoimmune disorder significantly associated with an increased risk of recurrent pregnancy loss(RPL)and obstetric complications such as preeclampsia and fetal growth restriction.Meanwhile,pregnancy can trigger disease activity or progression to defined connective tissue diseases(e.g.,systemic lupus erythematosus)in approximately 30％of UCTD patients.Therefore,screening for UCTD is essential in RPL patients.Confirmed cases require pre-pregnancy assessment(ensuring low disease activity)and close monitoring throughout pregnancy by collaboration between rheumatology and obstetrics teams.Recommended treatment includes low-dose aspirin and low-molecular-weight heparin anticoagulation to improve placental circulation,combined with hydroxychloroquine and low-dose prednisone to control disease activity and increase live birth rates.Postpartum rheumatology follow-up remains necessary to monitor for disease progression.关键词
未分化结缔组织病/复发性流产/诊断/治疗Key words
undifferentiated connective tissue disease/re-current spontaneous abortion/diagnosis/therapy分类
医药卫生引用本文复制引用
LI Rui,LYU Liang-jing..复发性流产合并未分化结缔组织病的诊治[J].中国实用妇科与产科杂志,2025,41(11):1084-1088,5.基金项目
国家重点研发计划(2022YFC2504601) National Key Research and Development Project of China(2022YFC2504601) （2022YFC2504601）
