中国实用妇科与产科杂志2025，Vol.41Issue(11)：1095-1099,5.DOI:10.19538/j.fk2025110109
难治性产科抗磷脂综合征的诊治
Diagnosis and treatment of refractory obstetric antiphospholipid syndrome
摘要
Abstract
Refractory obstetric antiphospholipid syndrome(ROAPS)refers to obstetric antiphospholipid syndrome in patients who still experience pregnancy loss,preeclampsia or HELLP syndrome,or preterm birth before 34 weeks of gestation despite standardized low-dose aspirin combined with low-molecular-weight heparin therapy.ROAPS is an urgent problem to be solved;however,there is still no uniform,standardized treatment.The more recognized treatment measures are to strengthen anti-coagulation with aspirin and low-molecular-weight heparin and use hydroxychloroquine and glucocorticoids for immune regulation.Other treatments like IVIG,therapeutic plasma exchange,TNF-α inhibitors and statins can also be considered when necessary.More large-sample and multicenter data are still needed to confirm the effectiveness and safety of these measures in the future.关键词
抗磷脂综合征,难治性,产科/低分子量肝素/羟氯喹/糖皮质激素/他汀类药物Key words
antiphospholipid syndrome,refractory,obstet-ric/low-molecular-weight heparin/hydroxychloroquine/corticosteroids/statins分类
医药卫生引用本文复制引用
YANG Li,ZHANG Hong..难治性产科抗磷脂综合征的诊治[J].中国实用妇科与产科杂志,2025,41(11):1095-1099,5.基金项目
国家自然科学基金面上项目(82071726) （82071726）
江苏省自然科学基金项目(BK20241791) National Natural Science Foundation of China-General Projects(82071726) （BK20241791）
Jiangsu Provincial Natural Science Foundation Project(BK20241791) （BK20241791）
