胆道良性疾病发病机制中胆道力学改变意义及应用前景
The significance and application prospects of biliary bio-mechanical alterations in the pathogenesis of benign bili-ary diseases
摘要
Abstract
Traditionally viewed as a passive conduit,the bili-ary system is now recognized as a highly coordinated hydraulic"pump-conduit-valve"system with intricate biomechanical properties.Biomechanical alterations in the biliary tract are not merely consequences of disease but are key driving factors in its pathogenesis and progression.The mechanism of solid and fluid mechanics in benign biliary diseases encompasses biliary geometry,sphincter of Oddi dynamics,the mechanical properties of the gallbladder and bile ducts,bile composition and rheological behavior,and their interplay in stone formation and inflammatory development.The application prospects of biliary biomechanics in clinical diagnosis and treatment in-clude patient-specific simulations based on computational flu-id dynamics,functional reconstruction in surgical procedures,and the development of novel pharmaceuticals and stents.In the future,multidisciplinary integration will advance biliary biomechanics from mechanistic research to clinical transla-tion,offering new avenues for precise and radical management of benign biliary diseases.关键词
胆道良性疾病/胆道力学/胆石形成/计算流体力学Key words
benign biliary diseases/biliary biomechanics/gallstone formation/computational fluid dynamics分类
医药卫生引用本文复制引用
QU Kai,LENG Hao-ze,LIU Chang..胆道良性疾病发病机制中胆道力学改变意义及应用前景[J].中国实用外科杂志,2025,45(11):1249-1252,1255,5.基金项目
"四大慢病"国家科技重大专项(No.2025ZD0551500、2025ZD0551501) （No.2025ZD0551500、2025ZD0551501）
陕西省卫生健康委围术期肝脏保护与再生医工融合科研创新团队项目(No.2025TD-01) （No.2025TD-01）
西安交通大学"肝脏力学与肝再生"学科交叉团队项目(No.xtr062025008) （No.xtr062025008）
陕西省重点产业创新链(群)(社会发展领域)项目(No.2024SF-ZDCYL-02-14) （群）
陕西省自然科学基础研究计划重点项目(No.2024JC-ZDXM-49) National Science and Technology Major Proj-ect for"Four Major Chronic Diseases"(No.2025ZD0551500,No.2025ZD0551501) （No.2024JC-ZDXM-49）
Shaanxi Provincial Health Commission Perioperative Liver Protection and Regeneration Med-Engi-neering Integration Scientific Research Innovation Team(No.2025TD-01) （No.2025TD-01）
"Liver Mechanics and Liver Regeneration"Interdisciplinary Team of Xi'an Jiaotong University(No.xtr062025008) （No.xtr062025008）
Shaanxi Provincial Key Industry Innovation Chain(Cluster)-Social Development Sector(No.2024SF-ZD-CYL-02-14) （Cluster）
Shaanxi Provincial Natural Science Basic Re-search Program Key Project(No.2024JC-ZDXM-49) （No.2024JC-ZDXM-49）
