内科2025，Vol.20Issue(5)：488-492,5.DOI:10.16121/j.cnki.cn45-1347/r.2025.05.05
手术前后γ-谷氨酰转肽酶水平变化与结直肠癌患者术后早期预后的关联分析
Association analysis of changes in gamma glutamyl transferase levels before and after surgery with early postoperative prognosis in patients with colorectal cancer
摘要
Abstract
Objective To explore the association between changes in serum gamma glutamyl transferase(GGT)levels before and after surgery and early postoperative prognosis in patients with colorectal cancer(CRC).Methods A retrospective analysis was conducted on 80 CRC patients who underwent radical surgery from July 2021 to June 2022.The patients were divided into the increased group(n=34)or the decreased group(n=46)according to the change in serum GGT level from baseline to postoperative day 1.The baseline clinicopathological data of the two groups were compared,and the 1-year postoperative survival of the two groups was analyzed using the Kaplan-Meier method and Log-rank test.Results The baseline serum GGT levels of the two groups before surgery were comparable(P>0.05).The positive rate of lymph node metastasis in the increased group was higher than that in the decreased group(70.59%vs.41.30%,χ²=6.744,P=0.009).At 1 year after surgery,the survival rate of the increased group(44.12%,15/34)was lower than that of the decreased group(65.22%,30/46),and the difference in survival curves was statistically significant(Log-rank χ²=4.474,P=0.034).Conclusion CRC patients with increased serum GGT levels after surgery have a higher risk of lymph node metastasis and a lower 1-year postoperative survival rate.Perioperative changes in GGT may serve as a reference indicator for prognostic assessment,but its independent predictive value needs to be further verified by studies.关键词
手术前后/γ-谷氨酰转肽酶/结直肠癌/预后/相关性Key words
Before and after surgery/Gamma glutamyl transferase/Colorectal cancer/Prognosis/Correlation分类
医药卫生引用本文复制引用
WEI Yana..手术前后γ-谷氨酰转肽酶水平变化与结直肠癌患者术后早期预后的关联分析[J].内科,2025,20(5):488-492,5.基金项目
右江民族医学院校级科研课题(yy2021sk109) （yy2021sk109）
