LI Kun 1LI Lulu 1NIE Zhifeng 1ZHANG Jianing 1ZHOU Jianchao1
作者信息
- 1. @@@1 Department of Pharmacy,2 Department of Obstetrics,the Third Affiliated Hospital of Zhengzhou University/Henan Provincial Maternity and Child Health Care Hospital,Zhengzhou 450052,Henan Province,China
- 折叠
摘要
Abstract
Objective To analyze and compare the effects of multi-oil fat emulsion and medium/long-chain fat emulsion on parenteral nutrition-associated liver disease(PNALD),liver function,and blood lipid indicators in very low birth weight premature infants.Methods A total of 80 very low birth weight premature infants who required long-term parenteral nutrition support(>2 weeks)were retrospectively selected,and they were divided into either a multi-oil fat emulsion group(n=40)or a medium/long-chain fat emulsion group(n=40)according to the type of fat emulsion used.The incidence of PNALD,liver function indicators(including total bilirubin[TBil],direct bilirubin[DBil],total bile acid[TBA],γ-glutamyl transferase[GGT],alkaline phosphatase[ALP],alanine aminotransferase[ALT],aspartate aminotransferase[AST],and albumin[Alb]),and blood lipid indicators(including total cholesterol,triglycerides,low-density lipoprotein cholesterol[LDL-C],and high-density lipoprotein cholesterol[HDL-C])were compared between the two groups of premature infants.Results The incidence of PNALD in the multi-oil fat emulsion group(0.00%)was lower than that in the medium/long-chain fat emulsion group(15.00%)(P<0.05).The serum levels of TBil,DBil,TBA,GGT,ALP,ALT,and AST in the multi-oil fat emulsion group were all lower than those in the medium/long-chain fat emulsion group,while the serum Alb level was higher than that in the medium/long-chain fat emulsion group(all P<0.05).The serum levels of total cholesterol,triglycerides,and LDL-C in the multi-oil fat emulsion group were all lower than those in the medium/long-chain fat emulsion group,and the serum HDL-C level was higher than that in the medium/long-chain fat emulsion group(all P<0.05).Conclusion Compared with medium/long-chain fat emulsion,the application of multi-oil fat emulsion in parenteral nutrition for very low birth weight premature infants may reduce the incidence of PNALD and improve liver function and blood lipid indicators.关键词
多种油脂肪乳/中/长链脂肪乳/肠外营养相关性肝病/高脂血症/早产儿Key words
Multi-oil fat emulsion/Medium/long-chain fat emulsion/Parenteral nutrition-associated liver disease/Hyperlipidemia/Premature infants分类
医药卫生
