ZHAO Jun 1WU Xiangzhen 1WANG Lidong2
作者信息
- 1. Graduate School of Chengde Medical University,Chengde 067000,Hebei Province,China||Department of Endocrinology,Rheumatology and Immunology,Chengde Central Hospital,Chengde 067000,Hebei Province,China
- 2. Department of Endocrinology,Rheumatology and Immunology,Chengde Central Hospital,Chengde 067000,Hebei Province,China
- 折叠
摘要
Abstract
Objective To explore the related factors of diabetic retinopathy(DR)in young and middle-aged patients with type 2 diabetes mellitus(T2DM),construct a nomogram prediction model,and evaluate its efficacy.Methods The clinical data of 537 young and middle-aged T2DM patients were collected.The patients were divided into the DR group(n=217)or the non-DR group(n=320)according to the presence or absence of DR.The clinical data of the two groups were compared.A multivariate logistic regression model was used to analyze the influencing factors of DR in young and middle-aged T2DM patients,and a nomogram prediction model was constructed.The receiver operating characteristic(ROC)curve was plotted to evaluate the predictive efficacy of the model.Results The duration of T2DM,family history of diabetes,urinary albumin-to-creatinine ratio,diabetic peripheral neuropathy,body mass index,subcutaneous fat area,fasting C-peptide,cystatin C,and lymphocyte-to-monocyte ratio were independent related factors for DR in young and middle-aged T2DM patients.The area under the ROC curve of the nomogram prediction model constructed based on the above related factors was 0.766(95%CI:0.726-0.806),with a sensitivity of 77.9%,a specificity of 64.1%,and a maximum Youden index of 0.419.Conclusion The duration of T2DM,family history of diabetes,urinary albumin-to-creatinine ratio,diabetic peripheral neuropathy,body mass index,subcutaneous fat area,fasting C-peptide,cystatin C,and lymphocyte-to-monocyte ratio are independent related factors for DR in young and middle-aged T2DM patients.The nomogram model constructed based on the above related factors demonstrates acceptable predictive efficacy.关键词
中青年/糖尿病视网膜病变/列线图模型/2型糖尿病/预测效能/影响因素Key words
Young and middle-aged/Diabetic retinopathy/Nomogram model/Type 2 diabetes mellitus/Predictive efficacy/Influencing factors分类
医药卫生
