中国中西医结合急救杂志2025，Vol.32Issue(4)：397-403,7.DOI:10.3969/j.issn.1008-9691.2025.04.003
脓毒症相关微小RNA研究热点的可视化分析
Visualization of the current status and hotspots of sepsis-associated microRNA research
摘要
Abstract
Objective To analyze the academic literature on sepsis-related microRNA(miRNA)at worldwide,and to dentify thematic hotspots and future research trends.Methods A bibliometric analysis was employed to retrieve the literature on sepsis-related miRNA published in the core collection of China National Knowledge Infrastructure(CNKI),and Web of Science(WOS)databases from January 1,2010,to January 1,2025,which met the article inclusion criteria,and used CiteSpace 6.3.1 software to perform the co-occurrence analysis of keywords,keyword emergence analysis,and cluster analysison;on the basis of these analyses,the keywords were sorted according to time to generate clustering time line figure to explore the current status and hotspot evolution process of sepsis-related miRNA.Results A total of 135 and 1 278 articles were retrieved from CNKI and the core collection of WOS databases,respectively.The frequency and centrality of keywords such as sepsis,prognosis,microRNA,acute lung injury,acute kidney injury,etc.were high in 135 documents in CNKI;in 1 278 documents in WOS core collection,the frequency and centrality of keywords such as expression,sepsis,inflammation,cells,micrornas,etc.were high;The top 10 keywords in the CNKI database in terms of burst intensity were:microRNA,inflammatory response,inflammatory factor,interleukin-10,tumor necrosis factor-α,acute respiratory distress syndrome,interleukin-35,septic shock,rat,tiny microRNA-155(miR-155);the top 10 keywords in the core collection of the WOS database in terms of burst intensity were:expression,NF-κB,microRNA,cells,induction,pathway,mechanisms,septic shock,mortality,cancer.Representative clustering tags in the CNKI are#0 prognosis,#1 miRNA,#2 septic shock;The representative clustering labels in the core collection of WOS database are#0 acute lung injury,#1 cancer,#2 septic shock,and so on.In CNKI and WOS core databases,the early keywords mainly revolve around the study of inflammatory factors and related mechanisms of sepsis,and the research center gradually shifts to the clinical physiological injuries as well as complications and mortality in the later stage,miRNA-126,AMP-activated protein kinase,interleukin-35 and other keywords have emerged.Among the top 10 most-cited English literature,researchers have paid particular attention to studying various miRNA as potential biomarkers of sepsis,including miR-146a,miR-223 and miR-146.Conclusions There are similarities and differences in the direction and hotspots of sepsis-related miRNA research in China and abroad.The research paradigm of sepsis has gradually shifted from the early clinical observation focusing on the overall complications and prognosis of patients to the basic research centered on the molecular mechanisms of inflammatory factors and signaling pathways.In this context,the study of miRNA as novel biomarkers for sepsis has been increasingly emphasized,and miRNA represent a promising direction for sepsis research,with potential applications both in basic research and clinical treatment.关键词
脓毒症/微小RNA/文献计量学/可视化分析Key words
Sepsis/MicroRNA/Bibliometric/Visual analysis引用本文复制引用
Yi Wei,Zhu Lijing,Zhang Like,Sun Ning,Li Zhi,Feng Ping,Liu Yingying,Wu Guosheng,Xia Zhaofan..脓毒症相关微小RNA研究热点的可视化分析[J].中国中西医结合急救杂志,2025,32(4):397-403,7.基金项目
上海市重中之重研究中心建设项目(2023ZZ02013) （2023ZZ02013）
海军军医大学第一附属医院(上海长海医院)基础医学研究专项(2023PY25) （上海长海医院）
海军军医大学"启航"人才计划(2023QH051) Key Research Center Construction Project of Shanghai(2023ZZ02013) （2023QH051）
Fundamental Medical Research Project of the First Affiliated Hospital of Naval Medical University(Shanghai Changhai Hospital)(2023PY25) （Shanghai Changhai Hospital）
"Qihang"Talent Program of Naval Medical University(2023QH051) （2023QH051）
