辐射研究与辐射工艺学报2025，Vol.43Issue(6)：1-15,15.DOI:10.11889/j.1000-3436.2025-0061
细胞外囊泡在肿瘤放疗抵抗调控及增敏策略中的研究进展
Progress of extracellular vesicles in tumor radiotherapy resistance regulation and sensitization strategies
摘要
Abstract
Extracellular vesicles(EVs)exert dual roles in tumor radiation resistance(RR)and radiosensitization.On one hand,tumor-derived EVs transport miRNAs(e.g.,miR-1246,miR-21),long non-coding RNAs(e.g.,NORAD),and proteins(e.g.,pATM,Survivin)to regulate DNA damage repair,cell cycle,and apoptosis pathways,thereby promoting RR development.On the other hand,EVs,leveraging their inherent properties as nanocarriers(biocompatibility,targeting capabilities,and blood-brain barrier penetration),serve as an ideal delivery platform for radiosensitizers.Engineering strategies(e.g.,surface modification,CRISPR/Cas9 loading)can further enhance EVs'targeting and functionality.Additionally,EVs influence radiotherapy efficacy by modulating the immune microenvironment(e.g.,PD-L1 transfer,M2 macrophage polarization),exhibiting a double-edged effect of"immune activation"and"immune suppression".Despite their immense potential in personalized radiotherapy sensitization,clinical translation faces challenges including large-scale production,standardization,and safety.This systematic review summarizes the molecular mechanisms and application progress of EVs in regulating tumor response to radiotherapy and enhancing sensitivity,offering new insights for optimizing radiotherapy strategies.关键词
细胞外囊泡/放疗抵抗/DNA损伤修复/放疗增敏Key words
Extracellular vesicles/Radioresistance/DNA damage repair/Radiosensitization分类
医药卫生引用本文复制引用
刘瑄,官成浓..细胞外囊泡在肿瘤放疗抵抗调控及增敏策略中的研究进展[J].辐射研究与辐射工艺学报,2025,43(6):1-15,15.基金项目
广东省基础与应用基础研究基金省市联合基金项目(2023A1515140082)、广东医科大学附属东莞第一医院第五批高层次人才科研资助计划资助项目(GCC2024006) （2023A1515140082）
广东医科大学附属东莞第一医院"攀峰100"联合培优计划资助项目(PF100-1-07) Supported by the Provincial and Municipal Joint Fund of the Guangdong Basic and Applied Basic Research Foundation(2023A1515140082),the Fifth Batch of High-Level Talent Research Support Program of Dongguan First People's Hospital,Affiliated to Guangdong Medical University(GCC2024006),and the"Peak Climb 100"Joint Training Program of The First Dongguan Affiliated Hospital of Guangdong Medical University(PF100-1-07) （PF100-1-07）
