辐射研究与辐射工艺学报2025，Vol.43Issue(6)：47-57,11.DOI:10.11889/j.1000-3436.2025-0046
探索乳腺癌保乳术后Hybrid-IMRT计划中3D-CRT和IMRT处方权重对计划质量的影响
Explore the influence of 3D-CRT and IMRT prescription weights on plan quality in Hybrid-IMRT plans after breast-conserving surgery for breast cancer
王园园 1赵思旭 2陈超 2刘俊伏 2陈坤志 3崔鑫2
作者信息
- 1. 吉林大学第一医院皮肤科 长春 130021
- 2. 梅河口市中心医院放疗科 梅河口 135000||吉林大学第一医院梅河医院放疗科 梅河口 135000
- 3. 吉林大学第一医院放疗科 长春 130021
- 折叠
摘要
Abstract
To analyze the dosimetric parameters of the plans under different prescription weights and explore the relationships between different prescription weights and plan quality by adjusting the proportion of Three-dimensional conformal radiation therapy(3D-CRT)and Intensity-modulated radiation therapy(IMRT)prescription weights in the hypofractionated radiotherapy Hybrid-IMRT plans after breast-conserving surgery for breast cancer.A retrospective analysis was conducted on 35 breast cancer patients who had received hypofractionated radiotherapy with a prescription of 42.72 Gy in 16 fractions.By adjusting the prescription weights of the 3D-CRT and IMRT plans,9 sets of Hybrid-IMRT plans were redesigned for each patient.The prescription weights of 3D-CRT and IMRT plans were as follows:90%/10%(C90%+I10%),80%/20%(C80%+I20%)…10%/90%(C10%+I90%).The volume of PTV received 100%prescription must be more than or equal to 95%.By analyzing parameters such as the MU,D2cc,Dmax,CI,V95%,V107%of the PTV and the irradiated dose of organs at risk(OAR),the relationships between the prescription weights of the 3D-CRT and IMRT plans and the quality of the plans were explored.When the prescription weight ratio of the 3D-CRT and IMRT plans was 90%/10%,the values of MU,D2cc and Dmax of the PTV were the lowest,the V107%value of the PTV was the smallest,and the irradiated doses of OARs were the lowest,especially for the ipsilateral lung and heart(p<0.001).With the increase in the prescription weight of the IMRT plans,the dosimetric parameters of the PTV in the Hybrid-IMRT plans did not change significantly,but the dosimetric indices of the OARs tended to deteriorate.When the prescription weight ratio of 3D-CRT and IMRT plans is 90%/10%,the dosimetric parameters of the PTV and OARs in the Hybrid-IMRT plan are optimal.关键词
乳腺癌/保乳术/大分割放射治疗/混合调强放射治疗Key words
Breast cancer/Breast-conserving surgery/Hypofractionated radiotherapy/Hybrid-IMRT分类
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王园园,赵思旭,陈超,刘俊伏,陈坤志,崔鑫..探索乳腺癌保乳术后Hybrid-IMRT计划中3D-CRT和IMRT处方权重对计划质量的影响[J].辐射研究与辐射工艺学报,2025,43(6):47-57,11.
