广西医科大学学报2025，Vol.42Issue(6)：861-869,9.DOI:10.16190/j.cnki.45-1211/r.2025.06.010
血浆蛋白与冠心病风险:前瞻性队列与孟德尔随机化研究
Plasma proteins and the risk of coronary artery disease:a prospective cohort and mendelian randomization study
摘要
Abstract
Objective:To investigate the association between plasma proteins and coronary artery disease(CAD)risk using data from the UK Biobank.Methods:Cox proportional hazards models were applied to assess prospec-tive associations of 2,911 proteins with CAD incidence.Pathway enrichment analysis was performed to identify relevant biological processes.Two-sample Mendelian randomization(MR)and colocalization analyses were con-ducted to infer causal relationships,and the clinical translational potential of key proteins was evaluated using DrugBank databases.Results:During a median follow-up of 14.52 years,3,760 incident CAD cases were docu-mented.A total of 508 proteins were identified to be significantly associated with the risk of CAD,and these pro-teins were enriched in atherosclerosis-related pathways.MR analysis confirmed 27 proteins with causal evidence for CAD.Colocalization analysis supported shared causal genetic variants between CAD and PCSK9/IFI30 pro-teins.Drug target validation indicated existing pharmacological development potential for several proteins.Con-clusion:This study identifies key plasma proteins associated with CAD risk and demonstrates their causal roles,providing a theoretical foundation for elucidating disease mechanisms and developing early prediction models and precision treatment strategies.关键词
血浆蛋白/冠心病/队列研究/孟德尔随机化/共定位分析/药物靶点Key words
plasma proteins/coronary artery disease/cohort study/Mendelian randomization/colocalization analysis/drug target分类
医药卫生引用本文复制引用
吴勤婷,黄代政..血浆蛋白与冠心病风险:前瞻性队列与孟德尔随机化研究[J].广西医科大学学报,2025,42(6):861-869,9.基金项目
广西重点研发计划项目(No.桂科AB20072003) （No.桂科AB20072003）
