广西医科大学学报2025，Vol.42Issue(6)：888-900,13.DOI:10.16190/j.cnki.45-1211/r.2025.06.013
血清褪黑素与维生素D的交互及联合作用影响超重与肥胖的风险
The interaction and joint effect of serum melatonin and vitamin D on the risk of overweight and obesity
摘要
Abstract
Objective:To investigate the interaction and joint effect of serum melatonin(MT)and vitamin D(Vit D)on the risk of overweight and obesity,and to explore the mediating role of metabolic indicators.Meth-ods:This cross-sectional study enrolled 3,739 health examinees,who were categorized by body mass index(BMI)into non-overweight/obesity(n=2,029)and overweight/obesity(n=1,710)groups,and subsequently strati-fied by median serum MT levels and clinical Vit D status(sufficient,insufficient/deficient).Multiple linear regres-sion and logistic regression models were employed to analyze the independent and joint effect of MT and Vit D on BMI and the risk of overweight/obesity.Subgroup analyses were conducted to examine potential effect hetero-geneity across different populations,and mediation analysis was performed to assess the mediating effect of meta-bolic parameters.Results:Multivariate-adjusted models revealed a significant multiplicative interaction between serum MT and Vit D on BMI(interaction term,β=-0.47,P=0.001).Analysis of their joint effect demonstrated that compared to the"low MT+insufficiency/deficiency Vit D"group,the"high MT+Sufficient Vit D"group was significantly associated with a lower BMI(β=-0.64,95%CI:-0.97 to-0.31,P＜0.001)and a reduced risk of overweight/obesity(OR=0.76,95%CI:0.61 to 0.93,P=0.010).Furthermore,a significant dose-response relation-ship was observed for this joint effect.Subgroup analyses indicated that this joint protective association was par-ticularly pronounced among older adults,individuals with type 2 diabetes mellitus,and those with hypertension.Mediation analysis further identified total cholesterol,triglycerides,low-density lipoprotein cholesterol,fasting blood glucose,and the triglyceride-glucose(TyG)index as significant mediators of the joint effect on BMI,ac-counting for 10.2%,33.4%,5.6%,18.3%,and 57.0%of the total effect,respectively.Conclusion:Serum MT and Vit D exhibit a joint protective effect against the risk of overweight and obesity.Maintaining relatively higher MT and sufficient Vit D levels may represent a potential strategy for preventing overweight and obesity.This protec-tive joint effect is likely mediated through the improvement of insulin resistance and lipid metabolism.关键词
褪黑素/维生素D/超重/肥胖/交互作用/联合效应Key words
melatonin/vitamin D/overweight/obesity/interaction effect/joint effect分类
医药卫生引用本文复制引用
高永芬,黄薛然,邓雨晴,苏涣,张学飞,莫曾南,李丹,林睿..血清褪黑素与维生素D的交互及联合作用影响超重与肥胖的风险[J].广西医科大学学报,2025,42(6):888-900,13.基金项目
广西医科大学青年科学基金资助项目(No.GXMUYSF202511) （No.GXMUYSF202511）
广西自然科学基金重点项目(No.2025GXNSFDA069012) （No.2025GXNSFDA069012）
国家自然科学基金资助项目(No.82273618) （No.82273618）
