广西医科大学学报2025，Vol.42Issue(6)：909-918,10.DOI:10.16190/j.cnki.45-1211/r.2025.06.015
膳食炎症和抗氧化指数与儿童青少年性激素水平的相关性分析
Correlation analysis of dietary inflammatory index and composite dietary antioxidant index with sex hormone levels in children and adolescents
摘要
Abstract
Objective:To explore the correlation of the dietary inflammatory index(DII)and composite dietary antioxidant index(CDAI)with sex hormone levels in children and adolescents.Methods:A cross-sectional analy-sis was conducted using data from the National Health and Nutrition Examination Survey(NHANES,2021-2023)of participants aged 6-19 years.Dietary intake was assessed via 24-hour dietary recall to calculate DII and CDAI.Spearman's rank correlation was used to analyze the correlations between DII,CDAI,and sex hormone levels.Multiple linear regression models were constructed to examine the effects of DII and CDAI on sex hor-mone levels,with subgroup analyses conducted.Results:A total of 800 subjects were included in the study.Mul-tiple linear regression results showed that DII was negatively correlated with the geometric means of total testos-terone(TT),free androgen index(FAI),and testosterone-to-estradiol ratio(TT/E2)(Model 1,β=-0.10 to-0.21,P＜0.001).In contrast,CDAI was positively correlated with the above indicators(Model 2,β=0.02 to 0.08,P＜0.05).Subgroup analysis and interaction tests indicated that the associations of DII and CDAI with certain sex hormones were statistically significant among children and adolescents of different age groups.The levels of TT,FAI,and TT/E2 in the high DII+high CDAI group were significantly higher than those in the other groups(all P＜0.05).Conclusion:Dietary factors are one of the key environmental elements influencing sex hormone regu-lation in children and adolescents.Both dietary inflammatory and antioxidant levels collectively affect sex hor-mone metabolism,with developmental stage specificity.The"high-inflammatory-high-antioxidant"dietary pat-tern may specifically interfere with androgen metabolism,providing a basis for interventions aimed at promoting adolescent reproductive health.关键词
膳食炎症指数/复合抗氧化指数/膳食因素/性激素/儿童青少年Key words
dietary inflammation index/composite dietary antioxidant index/dietary factors/sex hormone/chil-dren and adolescents分类
医药卫生引用本文复制引用
周素嫣,刘顺,覃凤翔..膳食炎症和抗氧化指数与儿童青少年性激素水平的相关性分析[J].广西医科大学学报,2025,42(6):909-918,10.基金项目
广西高校中青年教师科研基础能力提升项目(No.2023KY0088) （No.2023KY0088）
广西医科大学优秀博士计划 （）
