中北大学学报（自然科学版）2025，Vol.46Issue(6)：742-752,11.DOI:10.62756/jnuc.issn.1673-3193.2025.08.0002
双相脉冲电压刺激对大鼠运动调控的效果
Effects of Biphasic Pulses Voltage Stimulation on Motor Control in Rats
成珂 1刘虎 1赵瑞芳 1昝翔 2崔浩然 1崔建峰 1马久红 3丑修建 1张乐1
作者信息
- 1. 中北大学 电子测试技术重点实验室,山西 太原 030051||中北大学 铁电物理微纳器件与系统山西省重点实验室,山西 太原 030051
- 2. 山西医科大学附属山西省人民医院 神经外科,山西 太原 030012
- 3. 山西省人民医院 神经外科,山西 太原 030012
- 折叠
摘要
Abstract
Due to the inherent charge accumulation effect causing tissue damage and degrading electroding performance,monophasic pulses were found to be low control efficacy in studies of motor control in rats.In contrast,this problem could be figured out effectively by biphasic pulses through charge balance.How-ever,the specific advantages in motor control efficacy remain unclear for biphasic pulses,especially there was a lack of quantitative comparisons of key kinematic parameters.In this study,a biphasic pulse stimu-lation module based on the charge balance principle was designed to systematically compare the motor con-trol efficacy with that of monophasic pulses,using the Medial Forebrain Bundle(MFB)and Ventral Pos-teromedial nucleus(VPM)brain regions controlling forward movement and turning.It is found that the minimum stimulation amplitude required to drive movement in rats is significantly lower for biphasic pulses than that of monophasic pulses.Under the same stimulation parameters,biphasic pulses induces forward movement at a maximum speed of(12.50±0.23)m/min,which is 34.43%higher than that of monopha-sic pulses.At the same time,the maximum turning angle induced by biphasic pulses reaches(173.4±1.92)°,with an increase of 26.95%compared to monophasic pulses.关键词
运动神经调控/双相脉冲/最小刺激幅值/前进速度/转向角度Key words
motor nerve control/biphasic pulse/minimum stimulation amplitude/forward speed/turning angle分类
信息技术与安全科学引用本文复制引用
成珂,刘虎,赵瑞芳,昝翔,崔浩然,崔建峰,马久红,丑修建,张乐..双相脉冲电压刺激对大鼠运动调控的效果[J].中北大学学报（自然科学版）,2025,46(6):742-752,11.
