环境保护科学2025，Vol.51Issue(6)：50-56,7.DOI:10.16803/j.cnki.issn.1004-6216.202501044
微塑料暴露导致斑马鱼神经行为毒性效应
Microplastics exposure causes neurobehavioral toxic effects in zebrafish
摘要
Abstract
A Meta-analysis was conducted based on 40 peer-reviewed papers to investigate the effects of microplastic exposure on the neurotoxicity and locomotor behavior of zebrafish.The results showed that acetylcholine levels in zebrafish were significantly increased by 87.6%due to microplastics,and acetylcholinesterase activity as well as its gene expression were significantly inhibited(downregulated by 46.0%).Under conditions of long-term high-concentration exposure,the inhibitory effect of spherical microplastics with small particle sizes was the most significant.Sleep behavior of zebrafish was reduced by 32.1%and shoaling behavior was increased by 21.5%due to microplastics.The mechanism might be that locomotor behavior was regulated by interfering with neurotransmitter function and affecting neural conduction.Due to the limited sample size,the relevant molecular mechanisms have not been thoroughly explored.Further verification through experiments will be required in the future.A theoretical framework and scientific insights were provided by this study for the mechanism research on microplastic-induced neurobehavioral toxicity in zebrafish.关键词
微塑料/斑马鱼/神经毒性/运动行为/Meta分析Key words
microplastics/zebrafish/neurotoxicity/locomotor behavior/Meta-analysis分类
资源环境引用本文复制引用
闫振宇,霍达,张国徽..微塑料暴露导致斑马鱼神经行为毒性效应[J].环境保护科学,2025,51(6):50-56,7.基金项目
碳中和框架下的环境责任保险体系研究(KJHX2021063) （KJHX2021063）
中国科协"科创中国"绿色智慧工业园区建设科技服务团(KJFWT2024-01) （KJFWT2024-01）
