影像科学与光化学2026，Vol.44Issue(1)：14-20,27,8.DOI:10.7517/issn.1674-0475.2026.01.02
子宫动脉血流动力学与血清CA125、NLR、INHB联合诊断卵巢子宫内膜异位囊肿及介入超声硬化术治疗后复发情况分析
Combined Diagnosis of Ovarian Endometriosis Cyst by Uterine Artery Hemo-dynamics and Serum CA125,NLR,INHB and Analysis of Recurrence after Interventional Ultrasound Sclerotherapy
摘要
Abstract
Objective:To investigate the diagnosis of ovarian endometrioma(OEM)by uterine artery hemodynamics combined with serum carbohydrate antigen 125(CA125),neutrophil lymphocyte ratio(NLR),inhibin B(INHB)and the recurrence after interventional ultrasound sclerotherapy.Methods:132 patients with OEM admitted to our hospital from March 2020 to March 2021 were selected as the OEM group,and 50 patients with ovarian simple cysts were selected as the control group.The hemodynamic indicators of the non cyst side uterus and cyst side uterus arteries in OEM patients were analyzed,including resistance index(RI),pulsation index(PI),peak systolic velocity/end diastolic velocity(S/D).The serum levels of CA125,NLR,and INHB were compared between the OEM group and the control group,and the ROC curve was analyzed.The value of combining PI,S/D,CA125,NLR,and INHB in the diagnosis of OEM.Follow up for 2 years,analyze the recurrence rate after OEM interventional ultrasound sclerotherapy treatment,compare the clinical data and RI,PI,S/D,CA125,NLR,INHB values between the non recurrence group and the recurrence group,and analyze the influencing factors of recurrence after OEM interventional ultrasound sclerotherapy treatment using a logistic regression model.Results:Compared with the non cyst side uterus,the RI,PI,and S/D of the cyst side uterine artery were significantly increased(P<0.05).Compared with the control group,the levels of CA125 and NLR in the OEM group were significantly increased(P<0.05),while the levels of INHB were significantly reduced(P<0.05).Drawing the ROC curve,it was found that when the cutoff values were 0.93,2.34,6.34,45.89,1.76,and 25.46,the combination of RI,PI,S/D,CA125,NLR,and INHB had the highest efficacy in diagnosing OEM,significantly superior to individual detection of various indicators(P<0.05);Following up for 2 years,26 out of 132 OEM patients experienced recurrence after interventional ultrasound sclerotherapy,with a recurrence rate of 19.70%.There were no significant differences between the two groups in cyst diameter,fertility history,cyst location,or the proportion of patients receiving post-operative GnRH-α therapy(P>0.05).Compared with the non recurrent group,the proportion of patients with age≥35 years old,cyst wall thickness≥0.3 cm,R-AFS stage Ⅲ～Ⅳ,RI,PI,S/D,CA125,NLR in the recurrent group were significantly increased(P<0.05),and INHB was significantly reduced(P<0.05).The Logistic regression model showed that age≥35 years old,cyst wall thickness≥0.3 cm,R-AFS stage Ⅲ～Ⅳ,and elevated RI,PI,S/D,CA125,and NLR values were risk factors for recurrence after OEM interventional ultrasound sclerotherapy(P<0.05),with INHB as the protective factor(P<0.05).Conclusion:The combination of uterine artery hemodynamics and serum CA125,NLR,and INHB in the diagnosis of OEM has certain clinical application value and is associated with recurrence after interventional ultrasound sclerotherapy.关键词
子宫动脉血流动力学/糖类抗原125/中性粒细胞与淋巴细胞比值/抑制素B/卵巢子宫内膜异位囊肿Key words
uterine artery hemodynamics/carbohydrate antigen 125/neutrophil lymphocyte ratio/inhibin B/ovarian endometrioma分类
医药卫生引用本文复制引用
姚亚丽,高崇于,方彦鹏,吴贤,文榆林..子宫动脉血流动力学与血清CA125、NLR、INHB联合诊断卵巢子宫内膜异位囊肿及介入超声硬化术治疗后复发情况分析[J].影像科学与光化学,2026,44(1):14-20,27,8.基金项目
2022年贵州省卫生健康委员会科学技术基金项目(gzwkj2022-181). （gzwkj2022-181）
