军事医学2025，Vol.49Issue(11)：829-838,10.DOI:10.7644/j.issn.1674-9960.2025.11.004
较高水平基线血红蛋白和红细胞压积可能促进高原适应
Higher baseline hemoglobin and hematocrit levels may promote high-altitude adaptation
王春晖 1管志峰 2丁太国 2张涛 2兰诗诗 1王恋英 2张红星1
作者信息
- 1. 安徽医科大学基础医学院,合肥 230032||国家蛋白质科学中心(北京),医学蛋白质组全国重点实验室,北京 102206
- 2. 中央军委训练管理部军事体育训练中心,北京 100072
- 折叠
摘要
Abstract
Objective To assess the potential causal association between baseline red blood cell(RBC)indices and high-altitude adaptation(HAA)among low-altitude residents by using the two-sample bidirectional Mendelian randomization(MR)analysis.Methods A total of 82 healthy volunteers from the plains were enrolled to find out whether baseline RBC indices measured under normoxia were correlated with the percent change in hemoglobin(HGB)after 4 hours of simulated hypobaric hypoxia exposure.Summary-level data from genome-wide association studies(GWAS)were collected for RBC indices among 162,255 residents on the plains of East Asia,and for HAA among a combined cohort of 10,295 Tibetans and non-Tibetan individuals of Eastern Asian ancestry.A two-sample bidirectional MR analysis was conducted to assess the potential causal association between baseline RBC indices and HAA.Results Significant negative correlations were observed between baseline RBC,HGB,and hematocrit(HCT)under normoxia on one hand and the percent change in HGB on the other hand after 4 hours of simulated hypobaric hypoxia exposure.Furthermore,when the subjects were dichotomized based on the percent change in HGB,baseline RBC indices could accurately predict the percent change in HGB post-hypoxia exposure(AUC=0.8491,95%CI=0.8178-0.8804).Forward MR analysis suggested that an inverse-variance weighted random-effects model supported a significant positive correlation of genetically predicted higher baseline HCT(odds ratio[OR]=1.023;95%CI=1.009-1.036;P=8.94×10-4)and HGB levels(OR=1.027;95%CI=1.011-1.043;P=7.02×10-4)with HAA.Reverse MR analysis indicated no significant reverse causation between HAA and baseline RBC indices.Conclusion Genetically predicted higher baseline levels of HCT and HGB may be helpful in the initial stage of HAA.关键词
孟德尔随机化/高原适应/红细胞指数/血红蛋白/红细胞压积Key words
Mendelian randomization/high-altitude adaptation/red blood cell indices/hemoglobin/hematocrit分类
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王春晖,管志峰,丁太国,张涛,兰诗诗,王恋英,张红星..较高水平基线血红蛋白和红细胞压积可能促进高原适应[J].军事医学,2025,49(11):829-838,10.
