军事医学2025，Vol.49Issue(11)：864-869,6.DOI:10.7644/j.issn.1674-9960.2025.11.009
失血性休克后线粒体损伤及治疗研究进展
Research advances in mitochondrial injury and treatment following hemorrhagic shock
摘要
Abstract
Hemorrhagic shock(HS)is a state of acute circulatory failure caused by massive hemorrhage that results in a sharp decrease in effective circulating blood volume and tissue hypoperfusion.HS easily triggers a series of complex pathophysiological changes,among which mitochondrial dysfunction is regarded as a key link.Mitochondria are the center of cellular energy production,which are involved in the regulation of apoptosis,oxidative stress response and immune regulation.With in-depth studies on the pathophysiological mechanism of HS,the role of mitochondria in HS has received more attention,but the mechanism of action remains elusive.This article reviews the pathophysiological characteristics,molecular regulatory mechanisms and research progress related to therapeutic drugs for mitochondrial injury after HS in order to contribute to subsequent research in this area.关键词
失血性休克/线粒体损伤/氧化应激/沉默信息调节因子1/线粒体保护剂Key words
hemorrhagic shock/mitochondrial injury/oxidative stress/silent information regulation 1/mitochondrial protectants分类
医药卫生引用本文复制引用
李俊英,刘磊..失血性休克后线粒体损伤及治疗研究进展[J].军事医学,2025,49(11):864-869,6.基金项目
湖北省医学青年拔尖人才项目[鄂卫通(2023)65号] （2023）
