环境与职业医学2025，Vol.42Issue(11)：1281-1288,8.DOI:10.11836/JEOM25034
挥发性有机物尿液代谢物与肾功能的关联及暴露风险因素
Association of urinary volatile organic compound metabolites with kidney functions and asso-ciated exposure risk factors
摘要
Abstract
[Background]Exposure to volatile organic compounds(VOCs)has been observed in both living and working environments.Volatile organic compounds metabolites(VOCMs)in urine can be used to assess the exposure to VOCs and potentially cause adverse effects on human body. [Objective]To quantitatively evaluate urinary VOCMs and their associations with renal function damage,and further trace the character-istics of potential environmental exposure to provide scientific evidence for effective prevention measures. [Methods]The study included a total of 6028 samples from four cross-sectional studies in the National Health and Nutrition Examination Survey(NHANES)conducted between 2011 and 2018,with exposure and health outcomes matched.Generalized linear models were em-ployed to assess the associations of urinary VOCMs(urinary creatinine adjusted)with urinary protein levels and estimated glomerular fil-tration rate(eGFR),with coviriables including gender,age,body mass index,education,smoking,alcohol consumption,exercise frequen-cy,diabetes,and hypertension.Weighted quantile sum(WQS)approach was utilized to analyze the effects of mixed exposure and to rank the contribution of individual VOCMs.The associations between VOCMs and associated living environments and occupational exposure characteristics were further investigated. [Results]Among the enrolled study participants(n=6028),a total of 11 urinary VOCMs were measured,with 10 metabolites having a positive rate of over 80%(84.59%-99.99%).There were 604 individuals(10.0%)having urinary protein abnormalities and 2831 individuals(47.0%)with eGFR reduced.Through a single and a multiple generalized linear model,5 VOCMs exhibited statistically significant associations with urinary protein abnormalities and/or reduced eGFR levels(P<0.05):N-acetyl-S-(N-methylaminocarbonyl)-L-cysteine(AMC),N-acetyl-S-(2-carboxyethyl)-L-cysteine(CEM),N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine(DHB),2-hydroxy-2-phenylacetic acid(MAD),and N-acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine(MB3).The WQS index indicated a significantly positive association between VOCMs and uri-nary protein abnormalities,and DHB contributed the most.The analysis on the potential sources of VOCs exposure showed that those who worked as a private entrepreneur or an employee(vs.government employees),rent houses(vs.owned real estate),had less number of rooms in the residence,fueled cars at self-service gas stations,and inhaled paint fumes in the past 48 h associated with higher VOCMs(P<0.05)and DHB contributed the most. [Conclusion]Multiple VOCMs in urine are associated with significantly kidney function injuries.The mixture exposure to VOCMs is signifi-cantly associated with higher risks of urinary protein abnormalities.Occupational category,housing ownership,ways to fuel a car,and in-halation of paint odors are closely related with VOCMs levels.关键词
挥发性有机化合物/肾功能损伤/尿液代谢物/暴露源/环境暴露Key words
volatile organic compound/renal function injury/urine metabolite/source of exposure/environmental exposure分类
医药卫生引用本文复制引用
谢奇,袁静宜,牛治平,胡远卓,刘奕玮,李久凤,赵卓慧..挥发性有机物尿液代谢物与肾功能的关联及暴露风险因素[J].环境与职业医学,2025,42(11):1281-1288,8.基金项目
上海市加强公共卫生体系建设三年行动计划项目(GWVI-11.2-XD11,GWVI-11.1-39,GWVI-11.1-01) （GWVI-11.2-XD11,GWVI-11.1-39,GWVI-11.1-01）
