临床口腔医学杂志2025，Vol.41Issue(12)：726-731,6.DOI:10.3969/j.issn.1003-1634.2025.12.006
口腔种植体周围炎患者血清LTB4、CCL21、TREM-1水平变化及临床意义
Changes and clinical significance of serum LTB4,CCL21,and TREM-1 in patients with peri-implantitis
摘要
Abstract
Objective:To explore the changes and clinical significance of serum leukotriene B4(LTB4),C-C motif chemokine ligand(CCL)21,and triggering receptor expressed on myeloid cells-1(TREM-1)in patients with peri-implantitis(PI).Methods:From January 2022 to January 2025,110 PI patients who accepted by our hospital were included as the stud-y subjects and set as group C.Another 110 healthy volunteers who were implanted with the same type of implant as PI pa-tients in our hospital were included and set as group B,110 healthy adults who underwent oral examinations were included as group A.ELISA method was used to detect serum LTB4,CCL21,and TREM-1.Pearson's correlation analysis was used to ana-lyse the correlation between serum LTB4,CCL21,TREM-1 levels and periodontal probing depth,bleeding index,C-reactive protein(CRP),and interleukin(IL)-6.Multivariate logistic regression was used to explore the relevant factors that affected the occurrence of PI.Receiver operating characteristic(ROC)curve analysis evaluated the predictive value of serum LTB4,CCL21,and TREM-1 levels for the occurrence of PI.Relative risk was used to explore the effects of different serum levels of LTB4,CCL21,and TREM-1 on PI.Results:Group C had larger periodontal probing depth,bleeding index,and serum CRP,IL-6,LTB4,CCL21,and TREM-1 than group A and group B(P＜0.05).There was no statistical difference in periodontal pro-bing depth,bleeding index,and serum CRP,IL-6,LTB4,CCL21,and TREM-1 between group A and group B(P＞0.05).Ser-um LTB4,CCL21,TREM-1 were positively correlated with periodontal probing depth,bleeding index,CRP,and IL-6(P＜0.001).LTB4,CCL21,and TREM-1 were risk factors for the occurrence of PI(P＜0.05).The AUC values of serum LTB4,CCL21,and TREM-1 alone and their combination for predicting PI occurrence were 0.792,0.829,0.810,and 0.929,respec-tively.The combined efficacy of the three was better(P＜0.05).Among patients undergoing implant treatment,elevated serum levels of LTB4,CCL21,and TREM-1 were associated with a 1.565-fold,1.705-fold,and 1.569-fold increased risk of peri-im-plantitis,respectively,compared to low levels(P＜0.001).Conclusion:Serum LTB4,CCL21,and TREM-1 in PI patients are elevated and positively correlated with periodontal probing depth,bleeding index,CRP,and IL-6.They are molecular indica-tors with promising application prospects for predicting PI.关键词
口腔种植体周围炎/白三烯B4/CC基序趋化因子配体21/人髓系细胞触发受体-1Key words
Peri-implantitis/Leukotriene B4/C-C motif chemokine ligand 21/Triggering receptor expressed on mye-loid cells-1分类
医药卫生引用本文复制引用
陈小玉,陈一..口腔种植体周围炎患者血清LTB4、CCL21、TREM-1水平变化及临床意义[J].临床口腔医学杂志,2025,41(12):726-731,6.基金项目
四川省医疗卫生与健康促进会科研项目(编号:KY2023SJ0244) （编号:KY2023SJ0244）
