汕头大学医学院学报2025，Vol.38Issue(4)：211-214,4.DOI:10.13401/j.cnki.jsumc.2025.04.004
粤东地区首批16例非亲缘造血干细胞捐献者临床特征与安全性分析
Clinical characteristics and safety profile of the first 16 unrelated hematopoietic stem cell donors in Eastern Guangdong
李敏红 1陈惠媚 1林绍泽 1苏永忠 1陶红芳 1邢学仰1
作者信息
- 1. 汕头大学医学院第一附属医院血液科,广东 汕头 515041
- 折叠
摘要
Abstract
Objective:To analyze the demographic characteristics,mobilization efficacy,and short-term safety of the first cohort of unrelated hematopoietic stem cell donors in Eastern Guangdong.Methods:A retrospective study was conducted on 16 healthy unrelated donors who underwent hematopoietic stem cell donation at the First Affiliated Hospital of Shantou University Medical College between November 2023 and September 2025.All donors received recombinant human granulocyte colony-stimulating factor[10 μg/(kg·d),administered subcutaneously in two divided doses]for mobilization,with collection initiated on day 5.Key laboratory parameters pre-and post-apheresis,quality of collected products,and adverse events were analyzed.Results:The median age of the 16 donors was 27 years,with a male predominance(81.3%).Students constituted the largest subgroup(37.5%,6/16),including five medical students.During mobilization,bone pain was reported in 56.3%(9/16)of donors.One donor(6.3%)experienced priapism,and another(6.3%)tested positive for SARS-CoV-2;neither event interrupted the collection process.All collections were successful,with a median CD34+cell count of 8.1×106/kg(based on recipient weight).Post-apheresis,mild hypokalemia occurred in 68.8%(11/16)of donors,which was promptly corrected with oral potassium supplementation.Conclusion:This study provides the first clinical data on unrelated hematopoietic stem cell donation in Eastern Guangdong,demonstrating that mobilization and collection within the regional system are safe and effective.The high proportion of student donors and the frequent occurrence of post-apheresis hypokalemia highlight key areas for optimizing donor management strategies.关键词
造血干细胞动员/造血干细胞采集/非亲缘供者/不良反应/安全性Key words
hematopoietic stem cell mobilization/hematopoietic stem cell collection/unrelated donors/adverse reactions/safety分类
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李敏红,陈惠媚,林绍泽,苏永忠,陶红芳,邢学仰..粤东地区首批16例非亲缘造血干细胞捐献者临床特征与安全性分析[J].汕头大学医学院学报,2025,38(4):211-214,4.
