时珍国医国药2025，Vol.36Issue(24)：4703-4708,6.DOI:10.70976/j.1008-0805.SZGYGY-2025-2415
当归补血汤治疗气血亏虚型血管性痴呆的临床疗效分析
Clinical efficacy of Danggui Buxue Decoction(当归补血汤)for vascular dementia with qi and blood deficiency syndrome and its impact on oxidative stress levels
摘要
Abstract
Objective To investigate the therapeutic effect of Danggui Buxue Decoction(当归补血汤,DGBXD)on vascular dementia(VD)with qi and blood deficiency syndrome and its influence on oxidative stress levels.Methods A total of 78 patients with VD of qi and blood deficiency were randomized into two groups.The control group received conventional Western medicine(WM)treatment,while the observation group was treated with DGBXD in addition to the conventional treatment.The clinical efficacy,traditional Chinese medicine(TCM)symptom scores,cognitive function and dementia severity scores,oxidative stress parameters,neurofactor levels,and incidence of adverse reactions during treatment were compared between the two groups before and after intervention.Results The obser-vation group demonstrated superior therapeutic efficacy compared to the control group(P<0.05).After 3 months of treatment,both groups showed significant improvements in the four TCM syndrome scores,Clinical Dementia Rating(CDR)score,and Montreal Cogni-tive Assessment(MoCA)score compared to baseline(P<0.05),with greater improvements observed in the observation group(P<0.05).After treatment,levels of malondialdehyde(MDA)and central nervous system specific protein(S-100β)were significantly decreased,while levels of SOD,GSH-Px,serotonin(5-HT),and nerve growth factor(NGF)were significantly increased in both groups(P<0.05),with the observation group exhibiting more pronounced improvements than the control group(P<0.05).No signifi-cant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Conclusion DGBXD combined with conventional WM demonstrates significant therapeutic effects in VD patients with qi and blood deficiency syndrome.It can alleviate clinical symptoms and oxidative stress levels,enhance cognitive and neurological function,and exhibits a favorable safety profile,sup-porting its clinical application and promotion.关键词
当归补血汤/气血亏虚型/血管性痴呆/临床疗效/氧化应激Key words
Danggui Buxue Decoction(当归补血汤)/Qi and blood deficiency syndrome/Vascular dementia/Clinical effi-cacy/Oxidative stress分类
医药卫生引用本文复制引用
杨海涛,龙寿峰,吴立群,艾莉伟,万婷..当归补血汤治疗气血亏虚型血管性痴呆的临床疗效分析[J].时珍国医国药,2025,36(24):4703-4708,6.基金项目
国家自然科学基金(82104757) （82104757）
广州市科技计划项目(202201011265) （202201011265）
