天津护理2025，Vol.33Issue(6)：651-655,5.DOI:10.3969/j.issn.1006-9143.2025.06.005
复发难治性淋巴瘤患者接受嵌合抗原受体T细胞临床试验真实体验的质性研究
Qualitative study on the real experience of patients with relapsed and refractory lymphoma receiving CAR-T clinical trial
摘要
Abstract
Objective:To understand the real experience of patients with relapsed and refractory lymphoma receiving chimeric antigen receptor T(CAR-T)cell therapy,and to provide references and suggestions for taking targeted nursing intervention.Methods:The descriptive phenomenological design was adopted in the study.Thirteen patients with relapsed and refractory lymphoma who received CAR-T clinical trials in the lymphoma ward of a gade A tertiary cancer hospital in Tianjin from January 2,2023 to February 1,2024 were interviewed by semi-structured methods.The data was analyzed,summarized and induced by Colaizzi 7-step analysis method.Results:The real experience of thirteen patients with relapsed and refractory lymphoma receiving CAR-T clinical trial can be summarized into three themes,including perceived trial benefits and risks(remission or disappearance of discomfort symptoms related to lymphoma,short-term symptoms related to CAR-T cell therapy,and long-term symptoms after CAR-T cell therapy),multiple complex psychological experiences(self-contradiction and conflict running through the whole process,traumatic stress disorder and post-traumatic growth coexisting,showing diversified expectations for treatment),and actively seeking diversified support(paying attention to treatment-related information,longing for continuity of professional medical services,and hoping to obtain family support).Conclusion:Patients with relapsed and refractory lymphoma have many experiences in CAR-T cell therapy.Medical staff should formulate targeted nursing strategies according to patients'specific conditions to help them recover as soon as possible and return to normal life.关键词
复发难治性淋巴瘤/CAR-T细胞疗法/临床试验/真实体验/质性研究Key words
Relapsed and refractory lymphoma/CAR-T cell therapy/Clinical trial/Real experience/Qualitative research分类
医药卫生引用本文复制引用
李文慧,贺瑾,冯丽娜,孙丽君..复发难治性淋巴瘤患者接受嵌合抗原受体T细胞临床试验真实体验的质性研究[J].天津护理,2025,33(6):651-655,5.基金项目
天津市医学重点学科建设项目(TJYXZDXK-011A) （TJYXZDXK-011A）
