生物技术进展2025，Vol.15Issue(6)：960-968,9.DOI:10.19586/j.2095-2341.2025.0088
mRNA药物的研究进展
The Research Progress of mRNA Drugs
摘要
Abstract
In recent years,mRNA drugs have accelerated their expansion into the pharmaceutical field as a disruptive biomedical technology.Owing to advantages such as short development cycles,rapid response capabilities,and significant therapeutic po-tential for previously"undruggable"targets,mRNA drugs offer new solutions to major medical challenges including viral epidem-ics,cancer,and rare diseases.With continuous technological advances,researchers have made breakthroughs in key areas such as molecular design and delivery systems.To date,more than 85 mRNA drug candidates have entered Phase Ⅱ/Ⅲ clinical trials globally,greatly boosting confidence in their therapeutic prospects.This article detailed structural modifications of in vitro tran-scribed mRNA,delivery systems for mRNA drugs,and their research progress and development trends across various disease ar-eas,aiming to serve as a reference for research engaged in mRNA drug development.关键词
mRNA药物/递送系统/体外转录mRNA/结构修饰Key words
mRNA drugs/delivery system/in vitro transcribed mRNA/structural modification分类
生物科学引用本文复制引用
薛雯,江一帆,贾宇,杨丽萍..mRNA药物的研究进展[J].生物技术进展,2025,15(6):960-968,9.基金项目
河北省生物医药创新专项(23372404D). （23372404D）
