生物技术进展2025，Vol.15Issue(6)：977-984,8.DOI:10.19586/j.2095-2341.2025.0082
靶向组蛋白乙酰化防治缺血性脑卒中的研究进展
Research Advances in Targeting Histone Acetylation for the Prevention and Treatment of Ischemic Stroke
摘要
Abstract
Ischemic stroke(IS)is a neurological disorder caused by cerebrovascular occlusion or stenosis leading to inadequate cerebral blood supply,resulting in brain tissue damage that severely affects patient survival and prognosis.Histone acetylation,a post-translational modification dynamically regulated by histone acetyltransferase(HAT)and histone deacetylase(HDAC),in-fluences IS pathogenesis by modulating gene expression related to microglial polarization,apoptosis,and ferroptosis.Studies demonstrate that interventions targeting histone acetylation through natural compounds,small-molecule drugs,and biopharma-ceuticals can effectively mitigate neuronal damage and exert neuroprotective effects.This review focused on histone acetylation to elucidate its regulatory mechanisms in IS progression and its potential as a therapeutic target,aiming to provide theoretical foun-dations for the subsequent clinical IS treatment.关键词
缺血性脑卒中/组蛋白/乙酰化修饰/去乙酰化修饰Key words
ischemic stroke/histones/acetylation modification/deacetylation modification分类
生物科学引用本文复制引用
王胜利,陈义汝,关运祥..靶向组蛋白乙酰化防治缺血性脑卒中的研究进展[J].生物技术进展,2025,15(6):977-984,8.基金项目
河南省中医药科学研究专项课题(2024ZY2002) （2024ZY2002）
河南省中医药拔尖人才培养项目专项课题(2022ZYBJ06). （2022ZYBJ06）
