生物技术进展2025，Vol.15Issue(6)：985-991,7.DOI:10.19586/j.2095-2341.2025.0093
基于Nrf2信号通路探讨氧化应激调控骨质疏松症的研究进展
Research Progress on the Regulation of Osteoporosis by Oxidative Stress Based on the Nrf2 Signaling Pathway
摘要
Abstract
Osteoporosis(OP)is a metabolic bone disease characterized by reduced bone mass and deterioration of bone microar-chitecture.An imbalance in bone remodeling represents the core pathological basis of OP,with oxidative stress playing a critical role in disrupting bone homeostasis and contributing to the development and progression of the disease.This article provided a systematic review of the structure and function of Nrf2,the biological effects of oxidative stress,and their interplay in the patho-logical mechanisms of OP.It is expected to promote future research combining single-cell omics,gene editing,and clinical trans-lation,deepen the understanding of the regulatory mechanism of Nrf2,and promote the development of OP diagnosis and treat-ment technologies targeting Nrf2.关键词
Nrf2信号通路/氧化应激/骨质疏松症Key words
Nrf2 signaling pathway/oxidative stress/osteoporosis分类
生物科学引用本文复制引用
杨青峰,赵思宇,陈夏暄,张翔,刘耀忠,蒋宜伟,刘佳瑞..基于Nrf2信号通路探讨氧化应激调控骨质疏松症的研究进展[J].生物技术进展,2025,15(6):985-991,7.基金项目
国家自然科学基金项目(82160916) （82160916）
2023年内蒙古自治区重点研发和成果转化项目(2023YFSH0049) （2023YFSH0049）
内蒙古自然科学基金项目(2025QN08033) （2025QN08033）
巴彦淖尔市科技计划项目(K202514). （K202514）
