武警医学2025，Vol.36Issue(12)：1045-1049,5.
卵裂期不同氧浓度对体外受精胚胎发育及妊娠结局的影响
Impact of oxygen concentrations during the cleavage stage on IVF embryo development and pregnancy outcomes
杨金姬 1石学颖 1李银丹 1李少杰 1王芳 1付浩 1胡春秀1
作者信息
- 1. 300162 天津,武警特色医学中心军人生殖医学科
- 折叠
摘要
Abstract
Objective To investigate the impact of oxygen concentrations during the cleavage stage on IVF embryo develop-ment and pregnancy outcomes.Methods This retrospective study analyzed 158 fresh blastocyst transfer cycles performed at the Repro-ductive Medicine Center of the Characteristic Medical Center of Chinese People's Armed Police Force between January 2022 and March 2024.Cycles were divided into two groups based on oxygen concentration during cleavage-stage culture:low-oxygen(5%O2,n=103)and high-oxygen(20%O2,n=53)groups.Embryo development parameters and clinical outcomes were compared between groups.Results No statistically significant differences were observed between groups in total fertilization rate,normal fertilization rate,cleavage rate,day-3 high-quality embryo rate,β-HCG positivity rate,clinical pregnancy rate,implantation rate,miscarriage rate,or live birth rate.The low-oxygen group demonstrated significantly higher day-3 usable embryo rate compared to the high-oxygen group(72.98%vs 67.90%,P<0.05).Conversely,the low-oxygen group showed significantly lower blastocyst formation rate(71.20%vs 79.57%,P<0.05)and usable blastocyst rate(66.03%vs 74.30%,P<0.05).Conclusion While low oxygen concentration during cleavage stage improves day-3 usable embryo rate,it does not enhance pregnancy outcomes in IVF-ET cycles.关键词
氧浓度/体外受精/胚胎发育/囊胚移植/妊娠结局Key words
oxygen concentration/in vitro fertilization/embryo development/blastocyst transfe/clinical outcome分类
医药卫生引用本文复制引用
杨金姬,石学颖,李银丹,李少杰,王芳,付浩,胡春秀..卵裂期不同氧浓度对体外受精胚胎发育及妊娠结局的影响[J].武警医学,2025,36(12):1045-1049,5.
