摘要
Abstract
Objective To explore the value of combined detection of tumor markers,inflammatory indi-cators,Albumin-bilirubin(ALBI)score and coagulation indicators in the differential diagnosis of gallbladder cancer and cholecystitis.Methods A total of 157 patients with gallbladder cancer(including accidental gall-bladder cancer and non-accidental gallbladder cancer)admitted to the hospital from February 2012 to February 2025 were selected and divided into the non-accidental gallbladder cancer group(39 cases)and the accidental gallbladder cancer group(118 cases).Meanwhile,100 patients with cholecystitis were selected as the cholecys-titis group.Compare the tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125),alpha-fetoprotein(AFP)]and inflammatory indicators[neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR)]of the three groups.The ALBI score,coagulation index[D-dimer(D-D),fibrinogen(FIB)]levels were analyzed.The correlation between each index and the severity of the disease was analyzed,and the receiver operating charac-teristic curve was used to evaluate the diagnostic efficacy of each index.Results Comparisons of CEA,CA125,CA19-9,NLR,MLR,D-D levels and ALBI scores among the three groups showed statistically signifi-cant differences(P<0.05).There was no statistically significant difference in the levels of AFP,PLR and FIB among the three groups(P>0.05).The levels of CEA,CA125,CA19-9,NLR,MLR,D-D and ALBI score were respectively positively correlated with the severity of the disease(from cholecystitis to accidental gallbladder cancer and then to non-accidental gallbladder cancer)(P<0.05).The diagnostic efficacy of the combined de-tection of CEA,MLR,D-D and ALBI score was significantly better than that of each individual indicator(AUC=0.778,P<0.05).Conclusion The combined detection of tumor markers,inflammatory indicators,ALBI score and coagulation indicators has important clinical value for the differential diagnosis of gallbladder cancer and cholecystitis,and can provide multi-dimensional reference basis for the precise clinical distinction between the two.关键词
胆囊癌/胆囊炎/肿瘤标志物/炎症指标/凝血指标/鉴别诊断Key words
Gallbladder carcinoma/Cholecystitis/Tumor marker/Inflammation index/Coagu-lation index/Differential diagnosis分类
医药卫生
