现代医药卫生2025，Vol.41Issue(12)：2760-2764,5.DOI:10.3969/j.issn.1009-5519.2025.12.005
小激活RNA在妇科常见恶性肿瘤中的作用研究进展
Research progress on the role of small activating RNA in common gynecological malignant tumors
摘要
Abstract
Objective Endometrial cancer,ovarian cancer,and cervical cancer are high-risk malignant tumors in gynecology,and their pathogenesis is complex and closely related to the dysregulation of tumor sup-pressor gene expression.The inactivation of tumor suppressor genes has been confirmed to be significantly correlated with the occurrence,development,prognosis,and drug resistance of gynecological malignancies.Small activated RNA(saRNA),as an emerging gene regulatory tool,opens up new avenues for tumor therapy by activating gene expression through a unique mechanism that specifically binds to the promoter region of target genes.Research has shown that saRNA plays a significant role in regulating the expression of tumor suppressor genes related to gynecological tumors and restoring their normal functions.It can effectively inhibit malignant biological behaviors such as tumor cell proliferation,apoptosis,and invasion.The article reviews the mechanism of action of saRNA and its application research progress in endometrial cancer,ovarian cancer,and cervical cancer,aiming to provide new theoretical support and treatment strategies for precision treatment of gynecological tumors.关键词
抑癌基因/小激活RNA/子宫内膜癌/卵巢癌/宫颈癌Key words
Tumor suppressor genes/Small activating RNA/Endometrial cancer/Oophoroma/Cervi-cal cancer分类
医药卫生引用本文复制引用
刘运淇,张冬,高琳芝,沈媛..小激活RNA在妇科常见恶性肿瘤中的作用研究进展[J].现代医药卫生,2025,41(12):2760-2764,5.基金项目
广东省广州市科技计划项目(202201020044). （202201020044）
