现代医药卫生2025，Vol.41Issue(12)：2775-2779,5.DOI:10.3969/j.issn.1009-5519.2025.12.008
住院患儿呼吸道合胞病毒和腺病毒感染情况研究
Respiratory syncytial virus and adenovirus infections in hospitalized children
摘要
Abstract
Objective To explore the epidemiological and etiological characteristics of children infected with respiratory syncytial virus(RSV)and adenovirus(ADV)infection in children,and to provide the basis for clinical treatment.Methods A total of 1 303 hospitalized children with ADV or RSV positive in Shaoxing Ma-ternity and Child Health Care Hospital from May 2023 to November 2024 were selected retrospectively.They were divided into RSV severe group(83 cases),ADV severe group(41 cases)and non-severe group(1 179 ca-ses)according to whether they were severe pneumonia or not.The non-severe group was further divided into RSV positive subgroup(821 cases)and ADV positive subgroup(358 cases).The clinical characteristics of the severe RSV group,the severe ADV group and the non-severe ADV group were compared,as well as laboratory indicators of RSV and ADV positive children[white blood cell count(WBC),platelet count(PLT),plateletcri t(PCT),C-reactive protein(CRP),creatine kinase isoenzyme MB(CK-MB),lactate dehydrogenase(LDH),ala-nine aminotransferase(ALT)and aspartate aminotransferase(AST)],and the seasonal distribution of RSV and ADV infection was analyzed.Results There were significant differences in age,mixed infection and un-derlying disease among the three groups(P<0.05).There was statistically significant difference in age be-tween the RSV severe group and the ADV severe and non severe groups(P<0.05).The mixed infection rate of severe RSV and ADV was significantly higher than that of non-severe RSV and ADV,and the difference was statistically significant(P<0.05).The rate of underlying disease in severe RSV group was higher than that in non-severe RSV group,and the difference was statistically significant(P<0.05).The levels of PLT,CK-MB and ALT in severe RSV group were significantly higher than those in RSV positive subgroup,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of WBC,PCT,CRP,LDH,and AST between the RSV severe group and RSV positive subgroup(P>0.05).The level of LDH in ADV severe group was higher than that in ADV positive subgroup,and the differ-ence was statistically significant(P<0.05).There were no statistically significant differences in the levels of WBC,PLT,PCT,CRP,CK-MB,ALT,and AST between the ADV severe group and the ADV positive sub-group(P>0.05).RSV infection was mainly concentrated in spring and autumn,and ADV infection was main-ly concentrated in spring and summer.The concentrated high incidence period of severe cases caused by RSV and ADV infection was highly consistent with its epidemic peak.Conclusion Severe infections caused by RSV and ADV are significantly associated with the clinical manifestations of the patients,and there is a significant increase in the levels of a variety of serum inflammatory markers.The concentrated high incidence period of severe cases is highly consistent with its epidemic peak.关键词
呼吸道病毒/儿童/感染/病原学/流行病学Key words
Respiratory viruses/Children/Infection/Etiology/Epidemiology分类
医药卫生引用本文复制引用
陈昊,丁杰锋,丁金龙,钦博..住院患儿呼吸道合胞病毒和腺病毒感染情况研究[J].现代医药卫生,2025,41(12):2775-2779,5.基金项目
浙江省基础公益研究计划项目(LGF22H190009) （LGF22H190009）
浙江省自然科学基金项目(LTGY24H190004). （LTGY24H190004）
