摘要
Abstract
Objective To analyze the relationship between cystatin C(CysC)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD)combined with pulmonary embolism(PTE).Methods A retrospective collection was conducted on clinical data and CysC indicators of 149 AECOPD patients with nor-mal renal function admitted to the hospital from December 2022 to December 2023.Based on CT pulmonary angiography results,they were divided into AECOPD group(98 cases)and combined group(AECOPD com-bined with PTE,51 cases).The indicators including CysC,white blood cell(WBC),neutrophil count(N),neu-trophil/lymphocyte ratio(NLR),D-dimer,high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),arterial partial pressure of carbon dioxide(PaCO2)levels,and p H between the two group were compared.Mul-tivariate logistic regression was used to analyze the high-risk factors for AECOPD combined with PTE,and the receiver operating characteristic(ROC)curve was used to evaluate the efficacy of CysC in predicting AE-COPD combined with PTE.Results The levels of CysC,WBC,N,NLR,D-dimer,hs-CRP,IL-6 and p H values in the merged group were higher than those in the AECOPD group,while the PaCO2 level was lower than that in the AECOPD group,with statistical significance(P<0.05).Elevated levels of N and CysC were high-risk factors for AECOPD combined with PTE.The area under the curve(AUC)predicted by CysC for AECOPD combined with PTE was 0.715(95%CI 0.62-0.81,P<0.001),with an optimal cutoff value of 0.945 mg/L,sensitivity of 66.7%,and specificity of 72.4%.Conclusion Acute inflammatory response and its severity play an important role in AECOPD combined with PTE,and serum CysC has certain clinical significance in predicting AECOPD combined with PTE.关键词
慢性阻塞性肺疾病急性加重/肺动脉栓塞/胱抑素C/危险因素Key words
Acute exacerbation of chronic obstructive pulmonary disease/Pulmonary embolism/Cystatin C/Risk factors分类
医药卫生
