现代医药卫生2025，Vol.41Issue(12)：2784-2787,2792,5.DOI:10.3969/j.issn.1009-5519.2025.12.010
广州市增城区2020-2022年健康人群百日咳毒素IgG抗体水平调查
Survey on IgG antibody levels against pertussis toxin in healthy population in Zengcheng district of Guangzhou from 2020 to 2022
摘要
Abstract
Objective To investigate the levels of IgG antibody against pertussis toxin(PT-IgG)in healthy population in Zengcheng District,Guangzhou.Methods From 2020 to 2022,the subjects were ran-domly selected from healthy population of all age groups in Zengcheng District for PT-IgG level survey.A to-tal of 300 subjects were selected,with 100 subjects each year.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum PT-IgG levels.The geometric mean concentration(GMC),positive rate and antibody distribution of PT-IgG in subjects with different characteristics were analyzed,and the GMC levels of PT-IgG in subjects with different vaccination intervals were compared.Results The GMC of PT-IgG in 300 subjects was 9.19 IU/mL(95%CI 8.26-10.22).Among them,53.7%(161/300)of the subjects had antibody levels below the detection limit(5 IU/mL),and the antibody positive rate was 2.33%(7/300).The PT-IgG positive rates of male and female subjects were 1.62%and 3.48%,respectively,and their GMC levels were 8.59 IU/mL(95%CI 7.55-9.78)and 10.23 IU/mL(95%CI 8.52-12.30),respectively.There were no statistically significant differences in PT-IgG positive rates,GMC level and antibody distribution between subjects of dif-ferent genders(P>0.05).The PT-IgG positive rates of local and non-local subjects were 2.63%and 0,respec-tively,and their GMC levels were 9.18 IU/mL(95%CI 8.19-10.29)and 9.21 IU/mL(95%CI 6.77-12.53),respectively.There were no statistically significant differences in PT-IgG positive rates,GMC level and antibody distribution between subjects from different regions(P>0.05).There was no statistically signif-icant difference in PT-IgG positive rate among subjects of different ages(P>0.05).However,there were sta-tistically significant differences in PT-IgG GMC level and antibody distribution among subjects of different ages(P<0.001).There was a statistically significant difference in PT-IgG GMC level among subjects with different vacci-nation intervals(P<0.001).Conclusion The PT-IgG level of healthy population in Zengcheng District,Guangzhou is relatively high,and the population under 20 years old has a higher risk of infection and transmission.关键词
百日咳/健康人群/抗体/疫苗Key words
Pertussis/Healthy population/Antibody/Vaccine分类
医药卫生引用本文复制引用
王盼,黄勇,郑志伟,叶梓莹,汤叔珍,廖燕冰..广州市增城区2020-2022年健康人群百日咳毒素IgG抗体水平调查[J].现代医药卫生,2025,41(12):2784-2787,2792,5.基金项目
广东省广州市卫生健康科技项目(20241A011066). （20241A011066）
