医学信息2025，Vol.38Issue(23)：89-92,4.DOI:10.3969/j.issn.1006-1959.2025.23.017
不同种类GnRHa对特发性中枢性性早熟女童生长指标及子宫体积的影响
Effects of Different Types of GnRHa on Growth Index and Uterine Volume in Girls with Idiopathic Central Precocious Puberty
摘要
Abstract
Objective To analyze the effects of different types of GnRHa on the growth index and uterine volume of girls with idiopathic central precocious puberty(ICPP).Methods A total of 40 ICPP girls admitted to Xinfeng County People′s Hospital from January 2022 to June 2024 were selected as the research objects.They were divided into control group and study group by random number table method,with 20 girls in each group.The control group was treated with subcutaneous injection of leuprorelin injection,and the study group was treated with intramuscular injection of triptorelin injection.The growth indexes[bone age progression,height standard deviation score(Ht-SD),body weight,BMI],uterine and ovarian volume changes and the incidence of adverse reactions(dizziness,gastrointestinal reactions,night sweats)were compared between the two groups.Results After treatment,the rate of bone age progression in both groups was slower than that before treatment(P＜0.05),and the rate of bone age progression in the study group was lower than that in the control group(P＜0.05).The Ht-SD of the two groups was higher than that before treatment(P＜0.05),and the Ht-SD of the study group was higher than that of the control group(P＜0.05).There was no significant difference in body weight and BMI between the two groups(P＞0.05).After treatment,the uterine volume and ovarian volume of the two groups were smaller than those before treatment(P＜0.05),and the uterine volume and ovarian volume of the study group were smaller than those of the control group(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).Conclusion Leuprorelin and triptorelin can effectively inhibit sexual development and improve growth potential in the treatment of ICPP girls,but triptorelin is more effective in slowing down the progression of bone age,increasing the height SD value and reducing the volume of reproductive organs,and the incidence of adverse reactions is lower and the safety is higher.It can be used as one of the preferred schemes for clinical treatment of ICPP girls.关键词
特发性中枢性性早熟/亮丙瑞林/曲普瑞林/生长指标/子宫体积Key words
Idiopathic central precocious puberty/Leuprorelin/Triptorelin/Growth indexes/Uterine volume分类
医药卫生引用本文复制引用
林立南,刘桥仲,赖胤婕..不同种类GnRHa对特发性中枢性性早熟女童生长指标及子宫体积的影响[J].医学信息,2025,38(23):89-92,4.基金项目
赣州市指导性科技计划项目(编号:GZ2023ZSF626) （编号:GZ2023ZSF626）
