医学信息2025，Vol.38Issue(23)：97-100,4.DOI:10.3969/j.issn.1006-1959.2025.23.019
替戈拉生联合高剂量阿莫西林二联方案根除治疗幽门螺杆菌的疗效观察
Observation on the Efficacy of Tegoprazan and High-dose Amoxicillin Dual Therapy for Eradicating Helicobacter Pylori
摘要
Abstract
Objective To explore the clinical effect of tegoprazan(TPZ)combined with high-dose amoxicillin(AMO)dual therapy in the eradication of Helicobacter pylori(Hp).Methods From June to December 2024,300 patients with Hp infection who were scheduled to undergo Hp eradication in Shangrao Guangxin District People's Hospital were selected and divided into observation group(n=142)and control group(n=158)by random number table method.The observation group was treated with TPZ+high-dose AMO dual therapy,and the control group was treated with bismuth-containing quadruple therapy.The Hp eradication rate,symptom score,clinical efficacy and adverse reactions were compared between the two groups.Results There was no significant difference in Hp eradication rate between the observation group and the control group(ITT analysis:85.92%vs.84.81%;PP analysis:88.03%vs.87.34%)(P＞0.05).The symptom scores(abdominal pain,abdominal distension,belching)of the two groups after treatment were lower than those before treatment(P＜0.05),but there were no significant difference between the two groups(P＞0.05).There was no significant difference in the effective rate between the observation group and the control group(91.55%vs.91.14%)(P＞0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(7.75%vs.15.82%),the difference was statistically significant(P＜0.05).Conclusion TPZ combined with high-dose AMO dual therapy can effectively improve the clinical symptoms of patients with Hp infection,its Hp eradication rate and comprehensive efficacy are comparable to those of conventional quadruple therapy,and it shows good drug safety.关键词
幽门螺杆菌/替戈拉生/阿莫西林Key words
Helicobacter pylori/Tegoprazan/Amoxicillin分类
医药卫生引用本文复制引用
陈淑平,徐铭,刘元东..替戈拉生联合高剂量阿莫西林二联方案根除治疗幽门螺杆菌的疗效观察[J].医学信息,2025,38(23):97-100,4.基金项目
江西省上饶市科技计划项目(编号:20241CZDX39) （编号:20241CZDX39）
