纳米材料传感器在免疫球蛋白G检测中的应用研究进展
Research Progress in the Application of Nanomaterial Sensors for Immunoglobulin G Detection
摘要
Abstract
Immunoglobulin G(IgG),serving as the pivotal effector molecule in humoral immunity,plays an irreplaceable role as a biomarker in disease diagnosis,therapeutic evaluation,and infection surveillance.Its accurate detection constitutes a fundamental technological cornerstone for personalized medicine.Nanomaterials have emerged as innovative solutions for constructing next-generation IgG biosensors by leveraging their exceptional surface-to-volume ratios,tunable surface chemical properties,and multifaceted signal transduction capabilities,thereby overcoming the inherent limitations of conventional detection methods in sensitivity,detection thresholds,and cost-effectiveness.This review systematically examines recent advancements in IgG detection biosensors utilizing noble metal nanomaterials,metal derivative nanomaterials,carbon nanomaterials,quantum dots,and rare-earth-doped upconversion nanoparticles.Through comparative analysis of their advantages and disadvantages,we provide critical insights for developing high-sensitivity,cost-efficient,and portable IgG detection platforms.关键词
纳米材料/生物标志物/生物传感器/免疫球蛋白G/IgG检测Key words
Nanomaterials/Biomarker/Biosensor/Immunoglobulin G/IgG detection分类
化学化工引用本文复制引用
宿欣瑶,赵伟馨,王施晗,代佳珍,王尚洋,彭微,李淑荣,张凌燕,孟佩俊..纳米材料传感器在免疫球蛋白G检测中的应用研究进展[J].应用化学,2025,42(12):1593-1607,15.基金项目
国家自然科学基金(Nos.82360656,81960601)、内蒙古自治区高等学校青年科技英才支持项目(No.NJYT23026)、内蒙古自治区自然科学基金(No.2023MS08009)、内蒙古自治区卫生健康委医疗卫生科技计划项目(No.202201383)、2024年度内蒙古自治区大学生创新创业训练计划项目(No.S202410130013)和包头医学院公共卫生与预防医学博士点建设专项科学研究基金(No.BYJJ-GWZX202508)资助 Supported by the National Natural Science Foundation of China(Nos.82360656,81960601),the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(No.NJYT23026),the Natural Science Foundation of Inner Mongolia Autonomous Region of China(No.2023MS08009),the Medical and Health Technology Plan Project of the Health Commission of Inner Mongolia Autonomous Region(No.202201383),the College Students'Innovation and Entrepreneurship Training Plan Program of Inner Mongolia Autonomous Region in 2024(No.S202410130013),and the Special Scientific Research Fund for the Construction of Doctoral Programs in Public Health and Preventive Medicine,Baotou Medical College(No.BYJJ-GWZX202508) （Nos.82360656,81960601）
