摘要
Abstract
Blood-contacting medical devices hold significant clinical applications,including vascular stents,artificial blood vessels,valves,and blood purification equipment,playing a vital role in safeguarding human health.However,these devices often trigger immune responses and thrombus formation during use,leading to suboptimal therapeutic outcomes.Additionally,bacterial contact on device surfaces during implantation may result in infections.Consequently,there is an urgent need to develop blood-contacting device surfaces with dual anticoagulant and antibacterial functionalities.This study addresses the issues of thrombosis and bacterial infections that can occur during the use of blood contact devices.Using electrospinning technology,a polyvinylidene fluoride(PVDF)micro-nano fiber membrane loaded with heparin and barium titanate(PVDF/Hep/BaTiO3)was prepared on the surface of a substrate material.The material's surface was characterized using scanning electron microscopy,Fourier transform infrared spectroscopy,and X-ray photoelectron spectroscopy.The study investigated the biocompatibility,hemocompatibility,and antibacterial properties of the constructed surface.The results showed that the micro-nano fibers containing heparin exhibit excellent anti-thrombotic properties,reducing platelet adhesion by 60%.The extracellular matrix-like structure of the micro-nano fibers,combined with heparin,enhances the material's ability to promote endothelial cell proliferation by 20%.Additionally,the hemolysis rate of the micro-nano fibers is less than 5%,and the cell viability is over 90%,indicating good biocompatibility.Furthermore,the barium titanate and PVDF in the micro-nano fibers work together to enhance the piezoelectric effect,killing over 90%of bacteria after ultrasonic pretreatment.Thus,the PVDF/Hep/BaTiO3 micro/nano fiber-modified membrane exhibits excellent cell proliferation promotion,anticoagulation,and antibacterial properties,providing a simple yet effective surface modification strategy for multifunctional optimization of blood-contacting medical devices.关键词
肝素/聚偏氟乙烯/抗凝/抗菌/压电性能Key words
Heparin/Polyvinylidene fluoride/Anticoagulant/Antibacterial/Piezoelectric effect分类
化学化工
