应用化学2025，Vol.42Issue(12)：1649-1660,12.DOI:10.19894/j.issn.1000-0518.250251
表皮细胞生长因子/伤科黄水/聚乙烯醇水凝胶创面敷料的制备及其性能
Preparation and Properties of Epidermal Growth Factor/Shangkehuangshui/Polyvinyl Alcohol Hydrogel Wound Dressing
摘要
Abstract
Shangkehuangshui(HS)is an in-house preparation of Foshan Traditional Chinese Medicine Hospital,used for the treatment of bone and soft tissue injuries.It exhibits anti-inflammatory,hemostatic,blood circulation-promoting,blood stasis-removing,and new tissue growth-enhancing effects.Currently,in clinical practice,HS is predominantly administered via the"wet compress"method,which has several limitations,including short duration of efficacy,low drug utilization rates,and operational inconvenience.In this study,a hydrogel containing HS was prepared using polyvinyl alcohol(PVA)as a medical excipient through irradiation.The hydrogel tensile strength reaches up to 70 kPa,and elongation at break surpasses 350%.Furthermore,in vitro drug release experiments revealed that both alkaloid and non-alkaloid components of HS achieve effective release.Cell proliferation assays indicated that the number of NIH3T3 cells cultured in PVA/EGF and PVA/HS hydrogels increased significantly by approximately 20%compared to the PVA group within one day following the addition of human epidermal growth factor(EGF).After seven days,the increase exceeded 30%,with statistically significant results(p＜0.0001).Rat skin repair experiments demonstrated that HS/PVA hydrogel exhibited comparable efficacy in promoting skin damage repair to the wet compress method of Traumatology Yellow Water Preparation.Moreover,EGF/HS/PVA hydrogel containing EGF showed superior capability in enhancing skin tissue repair.In conclusion,the application of EGF/HS/PVA hydrogel products prepared via irradiation can achieve or even surpass the therapeutic effects of Shangkehuangshui wet application.关键词
聚乙烯醇/伤科黄水/表皮细胞生长因子/载药水凝胶Key words
Polyvinyl alcohol/Shangkehuangshui/Epidermal growth factor/Wound dressing分类
化学化工引用本文复制引用
常永丰,何明丰,雷凯君,郑芳昊,周小松,武振旭,焦自学,章培标..表皮细胞生长因子/伤科黄水/聚乙烯醇水凝胶创面敷料的制备及其性能[J].应用化学,2025,42(12):1649-1660,12.基金项目
吉林省与中国科学院科技合作高技术产业化专项资金项目(No.2022SYHZ0022)资助 Supported by the Special Fund Project for High-tech Industrialization of Scientific and Technological Cooperation between Jilin Province and the Chinese Academy of Sciences(No.2022SYHZ0022) （No.2022SYHZ0022）
