医学信息2025，Vol.38Issue(23)：113-117,5.DOI:10.3969/j.issn.1006-1959.2025.23.023
吡格列酮对脓毒症急性肝损伤患者肝功能及炎症氧化应激的影响
Effect of Pioglitazone on Liver Function and Inflammatory Oxidative Stress in Sepsis Patients with Acute Liver Injury
摘要
Abstract
Objective To investigate the effects of pioglitazone on liver function and inflammatory oxidative stress in sepsis patients with acute liver injury.Methods A total of 90 sepsis patients with acute liver injury who were diagnosed and treated in our hospital from October 2019 to October 2024 were selected as the research objects.They were divided into control group and observation group by random number table method,with 45 patients in each group.The control group was treated with conventional treatment,and the observation group was treated with pioglitazone on the basis of the control group.The total effective rate of clinical treatment,liver function index,inflammatory oxidative stress response index,acute physiological function and chronic health status(APACHEⅡ)score,infection-related organ failure(SOFA)score,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(91.11%)was higher than that in the control group(80.00%)(P＜0.05).The serum total bilirubin(TBil),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).The malondialdehyde(MDA)in the two groups was lower than that before treatment,the superoxide dismutase(SOD)and catalase(CAT)were higher those that before treatment,and the MDA in the observation group was lower than that in the control group,and the SOD and CAT were higher than those in the control group(P＜0.05).The APACHEⅡscore and SOFA score of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group(11.11%)and the control group(8.89%)(P＞0.05).Conclusion Pioglitazone treatment can improve the clinical efficacy of sepsis patients with acute liver injury,improve the liver function indexes,reduce inflammatory oxidative stress injury,and promote the control of the patient's condition.It has no significant adverse reactions and has relatively good application value.关键词
吡格列酮/脓毒症/急性肝损伤/肝功能/炎症氧化应激Key words
Pioglitazone/Sepsis/Acute liver injury/Liver function/Inflammatory oxidative stress分类
医药卫生引用本文复制引用
袁晓春,陆恺,陈林祥,崔恒浩,许陈晨,潘春霞..吡格列酮对脓毒症急性肝损伤患者肝功能及炎症氧化应激的影响[J].医学信息,2025,38(23):113-117,5.基金项目
2019年度南通大学临床医学专项项目(编号:2019LY048) （编号:2019LY048）
